Author | Salles, Fernanda | |
Author | Bacellar, Andrea | |
Author | Amorim, Mirla | |
Author | Orge, Glória | |
Author | Sundberg, Michael | |
Author | Lima, Márcia | |
Author | Santos, Silvane | |
Author | Porto, Aurélia | |
Author | Carvalho Filho, Edgar Marcelino | |
Access date | 2018-06-15T18:41:33Z | |
Available date | 2018-06-15T18:41:33Z | |
Document date | 2013 | |
Citation | SALLES, F. et al. Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels. Transactions of The Royal Society of Tropical Medicine and Hygiene, v. 107, p. 526–529, 2013. | pt_BR |
ISSN | 0035-9203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/26915 | |
Description | Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | NIH Grants AI-079238, and the Brazilian National Research Council (CNPq); Fundação de Amparo a
Pesquisa do Estado da Bahia. EC is a senior investigator with CNPq. | pt_BR |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | HTLV-1 | pt_BR |
Subject in Portuguese | Strongyloides stercoralis | pt_BR |
Subject in Portuguese | Leucemia | pt_BR |
Subject in Portuguese | ATLL | pt_BR |
Subject in Portuguese | Receptor de interleucina-2 | pt_BR |
Subject in Portuguese | sIL-2R | pt_BR |
Title | Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/trstmh/trt052 | |
Abstract | Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL). Methods:We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis,
and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical
outcomes of HTLV-1 infection.
Results: Levels of TNFa and IFNg were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients
with HTLV-1 only (p , 0.05), and there was an increase in TNFa levels after anthelmintic treatment. Levels
of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased
sIL-2R levels (p,0.05). The one patient who developed ATLLwas coinfected with S. stercoralis.
Conclusion: These data showthat helminthic infection has a modulatory role inHTLV-1 infection and that S. stercoralis
may be a cofactor in the development ofATLL. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Stanford University School of Medicine. Stanford, CA, USA | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Faculdade de Medicina. Aracaju, SE, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Subject | HTLV-1 | pt_BR |
Subject | Strongyloides stercoralis | pt_BR |
Subject | Leukemia | pt_BR |
Subject | ATLL | pt_BR |
Subject | Interleukin-2 receptor | pt_BR |
Subject | sIL-2R | pt_BR |