Author | Leite, Ana Cristina Lima | |
Author | Barbosa, Fábio Fernandes | |
Author | Cardoso, Marcos Veríssimo de Oliveira | |
Author | Moreira, Diogo Rodrigo de Magalhães | |
Author | Coêlho, Lucas Cunha Duarte | |
Author | Silva, Elany Barbosa da | |
Author | Oliveira Filho, Gevanio Bezerra de | |
Author | Souza, Valdênia Maria Oliveira de | |
Author | Pereira, Valéria Rêgo A | |
Author | Reis, Luiza de Campos | |
Author | Ferreira, Paulo Michel Pinheiro | |
Author | Pessoa, Claudia | |
Author | Wanderley, Almir Gonçalves | |
Author | Mota, Fernanda Virgínia Barreto | |
Author | Silva, Teresinha Gonçalves da | |
Access date | 2018-06-13T16:30:02Z | |
Available date | 2018-06-13T16:30:02Z | |
Document date | 2014 | |
Citation | LEITE, A. C. L. et al. Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes. Medicinal Chemistry Research, v. 23, p. 1701–1708, 2014. | pt_BR |
ISSN | 1054-2523 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/26872 | |
Description | Moreira, Diogo Rodrigo de Magalhães. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. A. C. L. Leite (&) F. F. Barbosa M. V. O. Cardoso
D. R. M. Moreira L. C. D. Coêlho E. B. da Silva
G. B. O. Filho V. M. O. de Souza
Departamento de Ciências Farmacêuticas, Centro de Ciências da
Saúde, Universidade Federal de Pernambuco, Recife,
PE 50740-520, Brazil
e-mail: acllb2003@yahoo.com.br
V. R. A. Pereira L. de C. Reis
Departamento de Imunologia, Centro de Pesquisas Ageu
Magalhães-FIOCRUZ, Recife, PE, Brazil
P. M. P. Ferreira
Departamento de Ciências Biológicas, Universidade Federal do
Piauí, Picos, Piauí 64607-670, Brazil
C. Pessoa
Departamento de Fisiologia e Farmacologia, Centro de Ciências
da Saúde, Universidade Federal do Ceará, Fortaleza,
CE 60430-270, Brazil
A. G. Wanderley
Departamento de Fisiologia e Farmacologia, Centro de Ciências
da Saúde, Universidade Federal de Pernambuco, Recife,
PE 50740-520, Brazil
F. V. B. Mota T. G. da Silva
Departamento de Antibio´ticos, Universidade Federal de
Pernambuco, Recife, PE 50740-520, Brazil | pt_BR |
Sponsorship | Brazilian National Research Council (CNPq), FACEPE, and FIOCRUZ | pt_BR |
Language | eng | pt_BR |
Publisher | Springer Verlag | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | N-ftaloil aminoácidos | pt_BR |
Subject in Portuguese | Anti-inflamatório | pt_BR |
Subject in Portuguese | Imunomodulador | pt_BR |
Title | Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes | pt_BR |
Type | Article | pt_BR |
Abstract | Abstract A series of phthalimide analogs were synthesized
by derivatization of phthalic anhydride, a highly toxic substance,
using a ‘‘one pot’’ condensation reaction to a-amino
acids. All phthaloyl amino acid derivatives presented anti-oral
inflammatory activity, but compounds 2e and 2g were found
to possess the best activities comparable to thalidomide.Most
of the compounds effectively suppressed nitric oxide production
inmurine cells stimulatedwith lipopolysaccharide.Nphthaloyl
amino acids did not exhibit any significant cytotoxicity
in vitro when tested against tumor cells as well as a
spleen cell culture of BALB/c mice. Compounds 2a, 2g, and
2h were able to inhibit TNF-a and IL-1b production by
macrophages. At the same concentration, thalidomide did not
exhibit significant inhibitory activity. | pt_BR |
Affilliation | Múltipla – ver em Notas | pt_BR |
Subject | N-phthaloyl amino acids | pt_BR |
Subject | Anti-inflammatory | pt_BR |
Subject | Immunomodulatory | pt_BR |