Author | Nunes, Sara | |
Author | Silva, Icaro Bonyek | |
Author | Ampuero, Mariana Rosa | |
Author | Noronha, Almério Libório Lopes de | |
Author | Souza, Lígia Correia Lima de | |
Author | Correia, Thaizza Cavalcante | |
Author | Cunha, Antonio Ricardo Khouri | |
Author | Boaventura, Viviane Sampaio | |
Author | Barral, Aldina Maria Prado | |
Author | Ramos, Pablo Ivan Pereira | |
Author | Brodskyn, Claudia Ida | |
Author | Oliveira, Pablo Rafael Silveira | |
Author | Tavares, Natalia Machado | |
Access date | 2018-05-10T16:49:33Z | |
Available date | 2018-05-10T16:49:33Z | |
Document date | 2018 | |
Citation | NUNES, S. et al. Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis. Frontiers in Immunology, v. 9, abr. 2018. | pt_BR |
ISSN | 1664-3224 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/26392 | |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmania braziliensis | pt_BR |
Subject in Portuguese | microRNA | pt_BR |
Subject in Portuguese | Pele | pt_BR |
Subject in Portuguese | Transcriptoma | pt_BR |
Subject in Portuguese | TREM-1 | pt_BR |
Subject in Portuguese | Leishmaniose humana | pt_BR |
Title | Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fimmu.2018.00640 | |
Abstract | Localized cutaneous leishmaniasis (LCL) is a chronic disease characterized by ulcerated skin lesion(s) and uncontrolled inflammation. The mechanisms underlying the pathogenesis of LCL are not completely understood, and little is known about posttranscriptional regulation during LCL. MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression and can be implicated in the pathogenesis of LCL. We investigated the involvement of miRNAs and their targets genes in human LCL using publicly available transcriptome data sets followed by ex vivo validation. Initial analysis highlighted that miRNA expression is altered during LCL, as patients clustered separately from controls. Joint analysis identified eight high confidence miRNAs that had altered expression (-1.5 ≤ fold change ≥ 1.5; p < 0.05) between cutaneous ulcers and uninfected skin. We found that the expression of miR-193b and miR-671 are greatly associated with their target genes, CD40 and TNFR, indicating the important role of these miRNAs in the expression of genes related to the inflammatory response observed in LCL. In addition, network analysis revealed that miR-193b, miR-671, and TREM1 correlate only in patients who show faster wound healing (up to 59 days) and not in patients who require longer cure times (more than 60 days). Given that these miRNAs are associated with control of inflammation and healing time, our findings reveal that they might influence the pathogenesis and prognosis of LCL. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Laboratório de Anatomia Patológica. Feira de Santana, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centre for Data and Knowledge Integration for Health. Salvador, Ba, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centre for Data and Knowledge Integration for Health. Salvador, Ba, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Subject | Leishmania braziliensis | pt_BR |
Subject | microRNA | pt_BR |
Subject | Skin | pt_BR |
Subject | Transcriptome | pt_BR |
Subject | TREM-1 | pt_BR |
Subject | Human leishmaniasis | pt_BR |