Author | Valverde, Ludmila de Faro | |
Author | Freitas, Raíza Dias de | |
Author | Pereira, Thiago de A. | |
Author | Resende, Marina F. de | |
Author | Agra, Ivan Marcelo Gonçalves | |
Author | Santos, Jean Nunes dos | |
Author | Reis, Mitermayer Galvão dos | |
Author | Sales, Caroline Brandi Schlaepfer | |
Author | Rocha, Clarissa Araújo Gurgel | |
Access date | 2018-04-19T13:34:05Z | |
Available date | 2018-04-19T13:34:05Z | |
Document date | 2018 | |
Citation | VALVERDE, L. F. et al. MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma. Applied Immunohistochemistry and Molecular Morphology, v. 26, n. 2, p. 120-125, 2018. | pt_BR |
ISSN | 1541-2016 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25947 | |
Sponsorship | National Council for Scientific and Technological Development (CNPq, Brazil). Foundation to Support Research in the State of Bahia (FAPESB, Bahia, Brazil). | pt_BR |
Language | eng | pt_BR |
Publisher | Lippincott, Williams & Wilkins | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Carcinoma de células escamosas | pt_BR |
Subject in Portuguese | Proliferação celular | pt_BR |
Subject in Portuguese | Imunohistoquímica | pt_BR |
Title | MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma | pt_BR |
Type | Article | pt_BR |
DOI | 10.1097/PAI.0000000000000397 | |
Abstract | The present study sought to evaluate and compare the immunoexpression of proteins minichromosome maintenance (MCM) 3 and Ki-67 in oral squamous cell carcinoma (OSCC) to assess the potential of these proteins as markers of cellular proliferation. Twenty-eight cases of OSCC, 9 of tumor-free resection margins (TM), and 4 of non-neoplastic oral mucosa (NNM) were subjected to immunohistochemistry to detect the expression of proteins MCM3 and Ki-67. All OSCCs demonstrated positivity for both proteins. In these tumors, greater MCM3 immunoreactivity was observed in comparison with Ki-67, whereas TMs and NNMs exhibited greater Ki-67 expression compared with MCM3. The immunoexpression of Ki-67 seemed to be influenced by the inflammatory process, particularly in TM and NNM. Our findings indicate that although both MCM3 and Ki-67 represent reliable markers of cellular proliferation in OSCC, as MCM3 expression does not appear to be influenced by external factors, this protein may emerge as a novel marker of cellular proliferation in these types of tumors. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Minas Gerais. School of Medicine of the Minas Gerais. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | AC Camargo Cancer Center. São Paulo, SP, Brasil | pt_BR |
Affilliation | Aristides Maltez Hospital. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Department of Pathology. Salvador, BA, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Department of Pathology. Salvador, BA, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / University of Bahia. School of Dentistry of the Federal. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil | pt_BR |
Subject | Squamous cell carcinoma | pt_BR |
Subject | Cellular proliferation | pt_BR |
Subject | Immunohistochemistry | pt_BR |