Author | Bezerra, Daniel Pereira | |
Author | Pessoa, Claudia do Ó | |
Author | Moraes Filho, Manoel Odorico de | |
Author | Saker Neto, Nicolau | |
Author | Silveira, Edilberto Rocha | |
Author | Lotufo, Leticia Veras Costa | |
Access date | 2018-04-19T12:54:21Z | |
Available date | 2018-04-19T12:54:21Z | |
Document date | 2013 | |
Citation | BEZERRA, D. P. et al. Overview of the therapeutic potential of piplartine (piperlongumine). European Journal of Pharmaceutical Sciences, v. 48, p. 453–463, 2013. | pt_BR |
ISSN | 0928-0987 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25943 | |
Description | Bezerra, Daniel Pereira. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | Capes (Coordenadoria de Apoio à Pesquisa e Ensino Superior), CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnológico), and Fapitec/SE (Fundação de Amparo à Pesquisa e à Inovação Tecnológica do Estado de Sergipe) | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Piplartine | pt_BR |
Subject in Portuguese | Piperlongumine | pt_BR |
Subject in Portuguese | Pimenta longa | pt_BR |
Subject in Portuguese | Piperaceae | pt_BR |
Subject in Portuguese | Medicina ayurvédica | pt_BR |
Title | Overview of the therapeutic potential of piplartine (piperlongumine) | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.ejps.2012.12.003 | |
Abstract | Piplartine (piperlongumine, 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)-pyridinone) is a biologically active alkaloid/amide from peppers, as from long pepper (Piper longum L. - Piperaceae). Long pepper is one of the most widely used in Ayurvedic medicine, which is used to treat many diseases, including tumors. The purpose of the current paper is to address to the chemical structure establishment and to systematically survey the published articles and highlight recent advances in the knowledge of the therapeutic potential of piplartine, establishing new goals for future research. The reported pharmacological activities of piplartine include cytotoxic, genotoxic, antitumor, antiangiogenic, antimetastatic, antiplatelet aggregation, antinociceptive, anxiolytic, antidepressant, anti-atherosclerotic, antidiabetic, antibacterial, antifungal, leishmanicidal, trypanocidal, and schistosomicidal activities. Among the multiple pharmacological effects of piplartine, its anticancer property is the most promising. Therefore, the preclinical anticancer potential of piplartine has been extensively investigated, which recently resulted in one patent. This compound is selectively cytotoxic against cancer cells by induction of oxidative stress, induces genotoxicity, as an alternative strategy to killing tumor cells, has excellent oral bioavailability in mice, inhibits tumor growth in mice, and presents only weak systemic toxicity. In summary, we conclude that piplartine is effective for use in cancer therapy and its safety using chronic toxicological studies should be addressed to support the viability of clinical trials. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, SE, Brasil | pt_BR |
Affilliation | Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Fortaleza, CE, Brasil | pt_BR |
Affilliation | Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Fortaleza, CE, Brasil | pt_BR |
Affilliation | Universidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica. Fortaleza, CE, Brasil | pt_BR |
Affilliation | Universidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica. Fortaleza, CE, Brasil | pt_BR |
Affilliation | Universidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Fortaleza, CE, Brasil | pt_BR |
Subject | Piplartine | pt_BR |
Subject | Piperlongumine | pt_BR |
Subject | Long pepper | pt_BR |
Subject | Piperaceae | pt_BR |
Subject | Ayurvedic medicine | pt_BR |