Author | Iñiguez, Alena Mayo | |
Author | Gastaldello, René | |
Author | Otsuki, Koko | |
Author | Balangero, Marcos | |
Author | Costa, Filipe Carvalho | |
Author | Remondegui, Carlos | |
Author | Vicente, Ana Carolina Paulo | |
Author | Gallego, Sandra | |
Access date | 2018-04-10T17:29:26Z | |
Available date | 2018-04-10T17:29:26Z | |
Document date | 2010 | |
Citation | IÑIGUEZ, Alena Mayo; et al. Correlation of HTLV-1 Tax Genetic Diversity With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis progression and HTLV-1a Genotypes in an HTLV-1 Endemic Region in Argentina. Journal of Medical Virology, v.82, p.1438–1441, 2010. | pt_BR |
ISSN | 0146-6615 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25742 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Vírus 1 Linfotrópico T Humano | pt_BR |
Subject in Portuguese | Genes pX | pt_BR |
Subject in Portuguese | subgrupo transcontinental | pt_BR |
Subject in Portuguese | Subgrupo japonês | pt_BR |
Subject in Portuguese | portadores saudáveis | pt_BR |
Subject in Portuguese | Argentina | pt_BR |
Title | Correlation of HTLV-1 Tax genetic diversity with HTLV-1 associated myelopathy/tropical spastic paraparesis progression and HTLV-1a genotypes in an HTLV-1 endemic region in Argentina | pt_BR |
Type | Article | |
DOI | 10.1002/jmv.21833 | |
Abstract | The oncoprotein Tax was characterized genetically from a large cohort of human T-cell lymphotropic virus type 1 (HTLV-1) seropositive individuals from the most endemic region of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV-1 infection in Argentina, the province of San Salvador de Jujuy. Sixteen HAM/TSP patients and 47 HTLV-1 healthy carriers were evaluated. Six Tax genetic polymorphisms were identified and observed in 70.8% of healthy carriers and 62.5% of HAM/TSP patients. Tax genetic polymorphisms were not associated with clinical status but A8344C polymorphism statistically provide a borderline protective effect of HAM/TSP outcome. Nucleotide diversity in healthy carriers was 0.00549, whereas HAM/TSP virus population revealed a low diversity of 0.00379, suggests a positive selection for Tax protein conservation in this group. It is concluded that tax genetic polymorphisms do not increase the risk of developing HAM/TSP in this endemic region. However, in spite of the low prevalence of HTLV-1aB genotype, statistical analysis revealed an important correlation of tax genetic signatures with HTLV-1aA trans-continental subgroup. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Sem afiliação | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | National University of Córdoba. School of Medicine. Institute of Virology. Laboratory of Human Lymphotropic Viruses. Córdoba, Argentina. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Sistemática Bioquímica. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | San Roque Hospital. San Salvador de Jujuy, Argentina. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | National University of Córdoba. School of Medicine. Institute of Virology. Laboratory of Human Lymphotropic Viruses. Córdoba, Argentina. | pt_BR |
Subject | tax genetic signatures | pt_BR |
Subject | healthy carriers | pt_BR |
Subject | San Salvador de Jujuy | pt_BR |
Subject | HAM/TSP outcome | pt_BR |
Subject | transcontinental subgroup | pt_BR |
Subject | Japanese subgroup | pt_BR |
e-ISSN | 1096-9071 | |
Embargo date | 2030-01-01 | |