Author | Borges, Andrezza Raposo | |
Author | Aires, Juliana Ramos de Albuquerque | |
Author | Higino, Taciana Mirely Maciel | |
Author | Medeiros, Maria das Graças Freire de | |
Author | Citó, Antonia Maria das Graças Lopes | |
Author | Lopes, José Arimatéia Dantas | |
Author | Figueiredo, Regina Celia Bressan Queiroz de | |
Access date | 2018-04-10T12:38:02Z | |
Available date | 2018-04-10T12:38:02Z | |
Document date | 2012 | |
Citation | BORGES, A. R. et al. Trypanocidal and cytotoxic activities of essential oils from medicinal plants of Northeast of Brazil. Experimental Parasitology, v. 132, n. 2, p. 123–128, out. 2012. | pt_BR |
ISSN | 1090-2449 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25710 | |
Sponsorship | Este trabalho foi apoiado pela CAPES e CPqAM - FIOCRUZ . | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Óleos essenciais | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Doença de Chagas | pt_BR |
Subject in Portuguese | Quimioterapia | pt_BR |
Subject in Portuguese | Citotoxicidade | pt_BR |
Title | Trypanocidal and cytotoxic activities of essential oils from medicinal plants of Northeast of Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.exppara.2012.06.003 | |
Abstract | Chagas disease, caused by Trypanosoma cruzi, is an important cause of mortality and morbidity in Latin America. There are no vaccines available, the chemotherapy used to treat this illness has serious side effects and its efficacy on the chronic phase of disease is still a matter of debate. In a search for alternative treatment for Chagas disease, essential oils extracted from traditional medicinal plants Lippia sidoides, Lippia origanoides, Chenopodium ambrosioides, Ocimum gratissimum, Justicia pectorales and Vitex agnus-castus were investigated in vitro for trypanocidal and cytotoxic activities. Essential Oils were extracted by hydrodistillation and submitted to chemical analysis by gas chromatography/mass spectrometry. The concentration of essential oils necessary to inhibit 50% of the epimastigotes or amastigotes growth (IC(50)) and to kill 50% of trypomastigote forms (LC(50)) was estimated. The most prevalent chemical constituents of these essential oils were monoterpenes and sesquiterpenes. All essential oils tested demonstrated an inhibitory effect on the parasite growth and survival. L. sidoides and L. origanoides essential oils were the most effective against trypomastigote and amastigote forms respectively. No significant cytotoxic effects were observed in mouse peritoneal macrophages incubated with essential oils which were more selective against the parasites than mammalian cells. Taken together, our results point towards the use of these essential oils as potential chemotherapeutic agent against T. cruzi. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal do Piauí. Campus Universitário Ministro Petrônio Portela-Ininga. Departamento de Química. Teresina, PI, Brazil. | pt_BR |
Affilliation | Universidade Federal do Piauí. Campus Universitário Ministro Petrônio Portela-Ininga. Departamento de Química. Teresina, PI, Brazil. | pt_BR |
Affilliation | Universidade Federal do Piauí. Campus Universitário Ministro Petrônio Portela-Ininga. Departamento de Química. Teresina, PI, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil. | pt_BR |
Subject | Essential oils | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Chagas disease | pt_BR |
Subject | Chemotherapy | pt_BR |
Subject | Cytotoxicity | pt_BR |
DeCS | Acanthaceae / química | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | Células Cultivadas | pt_BR |
DeCS | Chenopodium ambrosioides / química | pt_BR |
DeCS | Citotoxinas / efeitos adversos | pt_BR |
DeCS | Citotoxinas / farmacologia | pt_BR |
DeCS | Cromatografia Gasosa-Espectrometria de Massa | pt_BR |
DeCS | Concentração Inibidora 50 | pt_BR |
DeCS | Macrófagos Peritoneais / efeitos de drogas | pt_BR |
DeCS | Macrófagos Peritoneais / parasitologia | pt_BR |
DeCS | Ratos | pt_BR |
DeCS | Ratos, endogâmicos BALB C | pt_BR |
DeCS | Ocimum / química | pt_BR |
DeCS | Óleos voláteis / química | pt_BR |
DeCS | Óleos voláteis / isolamento e purificação | pt_BR |
DeCS | Óleos Voláteis / Farmacêuticos | pt_BR |
DeCS | Plantas Medicinais / Química | pt_BR |
DeCS | Tripanocidas Agentes / efeitos adversos | pt_BR |
DeCS | Tripanocidas Agentes / Farmacologia | pt_BR |
DeCS | Trypanosoma cruzi / efeitos de drogas | pt_BR |
DeCS | Verbenaceae / química | pt_BR |
Embargo date | 2050-01-01 | |