Author | Mugabe, Vánio André | |
Author | Ali, Sádia | |
Author | Chelene, Imelda | |
Author | Monteiro, Vanessa Onofre | |
Author | Guiliche, Onélia | |
Author | Muianga, Argentina Felisbela | |
Author | Mula, Flora | |
Author | António, Virgílio | |
Author | Chongo, Inocêncio | |
Author | Oludele, John | |
Author | Falk, Kerstin | |
Author | Paploski, Igor Adolfo Dexheimer | |
Author | Reis, Mitermayer Galvão dos | |
Author | Kitron, Uriel | |
Author | Kümmerer, Beate M | |
Author | Ribeiro, Guilherme de Sousa | |
Author | Gudo, Eduardo Samo | |
Access date | 2018-03-16T12:20:09Z | |
Available date | 2018-03-16T12:20:09Z | |
Document date | 2018 | |
Citation | MUGABE, Vánio André et al. Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus. Plos One, v. 13, n. 2, p. 1-13, 2018. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25341 | |
Sponsorship | Instituto Nacional de Saúde, Universidade Pedagógica de Quelimane (UPQ), and Ministério da Ciência e Tecnologia, Ensino Superior e Técnico Profissional, Mozambique; Conselho Nacional de Desenvolvimento
Científico e Tecnológico (CNPq), Instituto Gonçalo Moniz at Fundação Oswaldo Cruz, and
Instituto de Saúde Coletiva a Universidade Federal da Bahia, Brazil | pt_BR |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Febre Chikungunya | pt_BR |
Subject in Portuguese | Febre da dengue | pt_BR |
Subject in Portuguese | Transmissão | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Title | Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0192110 | |
Abstract | In January 2016, health authorities from Zambézia province, Mozambique reported the detection of some patients presenting with fever, arthralgia, and a positive result for chikungunya in an IgM-based Rapid Diagnostic Test (RDT). We initiated a study to investigate a potential chikungunya outbreak in the city of Quelimane. Methods/Principal findings
From February to June 2016, we conducted a cross-sectional study enrolling febrile patients
attending five outpatient health units in Quelimane. Serum from each patient was tested for
CHIKV and DENV, using IgM and IgG ELISA and qRT-PCR. Patients were also tested for
malaria by RDT. Entomological surveys were performed around patients' households, and
we calculated the proportion of positive ovitraps and the egg density per trap. A total of 163
patients were recruited, of which 99 (60.7%) were female. The median age was 28 years.
IgM and IgG anti-CHIKV antibodies were identified in 17 (10.4%) and 103 (63.2%) patients,
respectively. Plaque reduction neutralization assay confirmed the presence of anti-CHIKV
antibodies in a subset of 11 tested patients with positive IgG results. IgM anti-DENV antibodies
were found in 1 (0.9%) of 104 tested patients. Malaria was diagnosed in 35 (21.5%)
patients, 2 of whom were also IgM-positive for CHIKV. Older age and lower education level
were independently associated with the prevalence of IgG anti-CHIKV antibodies. Immature forms of Aedes aegypti were collected in 16 (20.3%) of 79 surveyed households. We also
found that 25.0% (16/64) of the traps were positive, with an average of 90.8 eggs per pallet.
Conclusions
Our investigation demonstrated that no CHIKV outbreak was ongoing in Quelimane; rather,
endemic transmission of the virus has been ongoing. Aedes aegypti mosquitoes are abundant,
but dengue cases occurred only sporadically. Further population-based cohort studies
are needed to improve our understanding of aspects related to the dynamics of arboviral
transmission in Mozambique, as well as in other parts of Sub-Saharan Africa. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Pedagógica de Quelimane. Zambezia, Mozambique. | pt_BR |
Affilliation | Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique. | pt_BR |
Affilliation | Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique. | pt_BR |
Affilliation | Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique. | pt_BR |
Affilliation | Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique. | pt_BR |
Affilliation | Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique. | pt_BR |
Affilliation | Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique. | pt_BR |
Affilliation | Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique. | pt_BR |
Affilliation | Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique. | pt_BR |
Affilliation | Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique. | pt_BR |
Affilliation | Public Health Agency of Sweden. Stockholm, Sweeden / Karolinska Institutet. Tumor and Cell Biology. Department of Microbiology. Stockholm, Sweden. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Subject | Chikungunya Fever | pt_BR |
Subject | Dengue fever | pt_BR |
Subject | Transmission | pt_BR |
Subject | Humans | pt_BR |