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https://www.arca.fiocruz.br/handle/icict/24918
COUNTRY OF RESIDENCE IS ASSOCIATED WITH DISTINCT INFLAMMATORY BIOMARKER SIGNATURES IN HIV-INFECTED PATIENTS
Author
Affilliation
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Bethesda, MD, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Integrado de Microbiologia e Imunoregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Bethesda, MD, USA
Leidos Biomedical Inc., Frederick, MD, USA
Leidos Biomedical Inc., Frederick, MD, USA
Duke University. Duke Hubert Yeargan Center for Global Health. Durham, NC, USA
Instituto Nacional de Ciencias Medicas y Nutricion. Departamento de Infectologia. Mexico City, Mexico
Instituto Nacional de Ciencias Medicas y Nutricion. Departamento de Infectologia. Mexico City, Mexico / Universidad Nacional Autonoma de Mexico. Facultad de Medicina. Division de Investigacion. Mexico City, Mexico
University of the Witwatersrand. Johannesburg, South Africa
Case Western Reserve University. Cleveland, OH, USA
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Bethesda, MD, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Integrado de Microbiologia e Imunoregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Bethesda, MD, USA
Leidos Biomedical Inc., Frederick, MD, USA
Leidos Biomedical Inc., Frederick, MD, USA
Duke University. Duke Hubert Yeargan Center for Global Health. Durham, NC, USA
Instituto Nacional de Ciencias Medicas y Nutricion. Departamento de Infectologia. Mexico City, Mexico
Instituto Nacional de Ciencias Medicas y Nutricion. Departamento de Infectologia. Mexico City, Mexico / Universidad Nacional Autonoma de Mexico. Facultad de Medicina. Division de Investigacion. Mexico City, Mexico
University of the Witwatersrand. Johannesburg, South Africa
Case Western Reserve University. Cleveland, OH, USA
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Bethesda, MD, USA
Abstract
Inflammation and coagulation biomarkers are independent predictors of morbidity and mortality in HIV-infected patients. The impact of country of residence on these biomarkers is unknown and was investigated in persons at similar stages of HIV infection. Methods: Cryopreserved plasma specimens were analysed from 267 ART-naive patients with CD4 cell counts <100 cells/μl
from Mexico (n=124) and South Africa (n=143). Biomarkers were compared and dimension reduction analyses were performed
to highlight biosignatures according to nationality, gender and tuberculosis co-infection.
Results: Mexican patients were significantly different from South Africans with regard to age, gender, CD4 cell count,
haemoglobin, presence of AIDS-defining illness and prevalence of active tuberculosis. After adjusting for baseline
characteristics, patients from Mexico had higher levels of IFN-γ, IL-8, and CXCL-10 whereas patients from South Africa
had higher levels of fibrinogen, LTB4, P-selectin, protein S, and sCD40 ligand. The effect of country on the profile of
biomarker expression was stronger than gender differences and tuberculosis co-infection.
Conclusion: Inflammation and coagulation biomarkers vary significantly by country. Further studies are needed to evaluate
how these differences may contribute to HIV pathogenesis and prognosis in diverse populations and how they can be
accounted for in studies using biomarkers as surrogate end points
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