Author | Mendes, Ramon Barreto | |
Author | Dias, Rosane Borges | |
Author | Figueiredo, Andreia Leal | |
Author | Gurgel, Clarissa Araújo | |
Author | Santana Filho, Manoel | |
Author | Melo, Leonardo Araújo | |
Author | Trierveiler, Marília | |
Author | Cury, Patrícia Ramos | |
Author | Leonardi, Rosalia | |
Author | Santos, Jean Nunes DOS | |
Access date | 2018-02-20T18:22:43Z | |
Available date | 2018-02-20T18:22:43Z | |
Document date | 2017 | |
Citation | MENDES, R. B. et al. Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study. Journal of Oral Pathology and Medicine, v. 46, p. 297–300, 2017. | pt_BR |
ISSN | 0904-2512 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24896 | |
Sponsorship | National Council for Scientific and Technological Development (CNPq) | pt_BR |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Ameloblastoma | pt_BR |
Subject in Portuguese | Glypican-3 | pt_BR |
Subject in Portuguese | Tumor odontogênico queratocístico | pt_BR |
Subject in Portuguese | Ttumores odontogênicos | pt_BR |
Title | Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/jop.12501 | |
Abstract | Glypican-3 is a cell surface proteoglycan that is found in embrionary tissues, and there are no studies investigating this protein in odontogenic tumor. Thus, the aim of this study was to investigate glypican-3 in a series of aggressive and non-aggressive odontogenic tumors. METHODS: Fifty-nine cases of tumors were divided into
aggressive odontogenic tumors (20 solid ameloblastomas,
four unicystic ameloblastoma, 28 KOTs including
five associated with Gorlin–Goltz syndrome) and nonaggressive
odontogenic tumors (five adenomatoid odontogenic
tumors and two calcifying cystic odontogenic
tumors) and analyzed for glypican-3 using immunohistochemistry.
RESULTS: Glypican-3 was observed in seven solid
ameloblastoma and eighteen keratocystic odontogenic
tumors including three of the five syndromic cases,
but there was no significant difference between syndromic
and sporadic cases (P > 0.05; Fisher’s exact Test). All
cases of unicystic ameloblastoma (n = 4), adenomatoid
odontogenic tumor (n = 5), and calcifying cystic odontogenic
tumor (n = 2) were negative.
CONCLUSIONS: This provided insights into the presence
of glypican-3 in odontogenic tumors. This protein
distinguished aggressive from non-aggressive odontogenic
tumors. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Department of Public Health. Salvador, BA, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Rio Grande do Sul. School of Dentistry. Department of Oral Pathology. Porto Alegre, RGS, Brazil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Salvador, BA, Brazil | pt_BR |
Affilliation | University of São Paulo. School of Dentistry. Department of Oral Pathology. São Paulo, SP, Brazil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Department of Periodontics. Salvador, BA, Brazil | pt_BR |
Affilliation | University of Catania. Department of Medical and Surgical Sciences. Catania, Italy | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Postgraduate in Human Pathology. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Salvador, BA, Brazil | pt_BR |
Subject | Ameloblastoma | pt_BR |
Subject | Glypican-3 | pt_BR |
Subject | Keratocystic odontogenic tumor | pt_BR |
Subject | Odontogenic tumors | pt_BR |