Author | Brito, Maria das Graças de Oliveira | |
Author | Dourado, Mayra Elizabeth Ferreira | |
Author | Polari, Ludmila | |
Author | Celestino, Daniela | |
Author | Carvalho, Lucas Pedreira de | |
Author | Queiroz, Adriano | |
Author | Carvalho Filho, Edgar Marcelino | |
Author | Machado, Paulo Roberto Lima | |
Author | Passos, Sara Timoteo | |
Access date | 2018-02-20T15:58:56Z | |
Available date | 2018-02-20T15:58:56Z | |
Document date | 2014 | |
Citation | BRITO, M. G. O. et al. Clinical and immunological outcome in cutaneous leishmaniasis patients treated with pentoxifylline. American Journal of Tropical Medicine and Hygiene, v. 90, n. 4, p. 617–620, 2014. | pt_BR |
ISSN | 0002-9637 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24887 | |
Description | CARVALHO FILHO, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | INCT-DT 573839/2008-5 and ICIDR grant AI088650. | pt_BR |
Language | eng | pt_BR |
Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose Cutânea | pt_BR |
Subject in Portuguese | Pentoxifilina | pt_BR |
Subject in Portuguese | Fator de necrose tumoral alfa | pt_BR |
Subject in Portuguese | Método duplo-cego | pt_BR |
Subject in Portuguese | Adulto | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Title | Clinical and immunological outcome in cutaneous leishmaniasis patients treated with pentoxifylline | pt_BR |
Type | Article | pt_BR |
DOI | 10.4269/ajtmh.12-0729 | |
Abstract | Pentoxifylline is a tumor necrosis factor-α (TNF-α) inhibitor that also attenuates the immune response and decreases tissue inflammation. The association of pentoxifylline with antimony improves the cure rate of mucosal and cutaneous leishmaniasis. In this randomized and double blind pilot trial, cure rate was higher, although not significant, in patients who received antimony plus pentoxifylline than in those patients receiving antimony plus placebo. A significant decrease in TNF-α and interferon-γ (IFN-γ) levels during therapy was more pronounced in the antimony plus pentoxifylline group, whereas CCL-3 (Chemokine [C-C motif] ligand 3) decreased similarly in both groups. The increased levels of CXCL-9 (Chemokine [C-X-C motif] ligand 9) during therapy were lower in the antimony plus pentoxifylline group. Therapy with pentoxifylline modifies cytokines and chemokines production, which may be associated with therapeutic outcome. | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology–Tropical Disease. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology–Tropical Disease. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology–Tropical Disease. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology–Tropical Disease. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology–Tropical Disease. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology–Tropical Disease. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology–Tropical Disease. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology–Tropical Disease. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Subject | Leishmaniasis, Cutaneous | pt_BR |
Subject | Pentoxifylline | pt_BR |
Subject | Tumor Necrosis Factor-alpha | pt_BR |
Subject | Double-Blind Method | pt_BR |
Subject | Adult | pt_BR |
Subject | Humans | pt_BR |