Author | Ferreira, Camila Pontes | |
Author | Cariste, Leonardo Moro | |
Author | Virgílio, Fernando dos Santos | |
Author | Moraschi, Barbara Ferri | |
Author | Monteiro, Caroline Brandão | |
Author | Machado, Alexandre M. Vieira | |
Author | Gazzinelli, Ricardo Tostes | |
Author | Romero, Oscar Bruna | |
Author | Ruiz, Pedro Luiz Menin | |
Author | Ribeiro, Daniel Araki | |
Author | Lannes-Vieira, Joseli | |
Author | Lopes, Marcela de Freitas | |
Author | Rodrigues, Mauricio Martins | |
Author | Vasconcelos, José Ronnie Carvalho de | |
Access date | 2018-02-20T15:28:11Z | |
Available date | 2018-02-20T15:28:11Z | |
Document date | 2017 | |
Citation | FERREIRA, Camila Pontes; et al. LFA-1 Mediates Cytotoxicity and Tissue Migration of Specific CD8+ T Cells after Heterologous Prime-Boost Vaccination against Trypanosoma cruzi Infection. Frontiers in Immunology, v.8, Article 1291, 16p, Oct. 2017. | pt_BR |
ISSN | 1664-3224 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24885 | |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Vacinação | pt_BR |
Subject in Portuguese | Migração | pt_BR |
Subject in Portuguese | Integrinas | pt_BR |
Subject in Portuguese | Linfócitos T | pt_BR |
Title | LFA-1 Mediates Cytotoxicity and Tissue Migration of Specific CD8+T Cells after Heterologous Prime-Boost Vaccination againstTrypanosoma cruziInfection | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fimmu.2017.01291 | |
Abstract | Integrins mediate the lymphocyte migration into an infected tissue, and these cells are essential for controlling the multiplication of many intracellular parasites such asTrypanosoma cruzi, the causative agent of Chagas disease. Here, we explore LFA-1 and VLA-4 roles in the migration of specific CD8+T cells generated by heterologous prime-boost immunization during experimental infection withT. cruzi. To this end, vaccinated mice were treated with monoclonal anti-LFA-1 and/or anti-VLA-4 to block these molecules. After anti-LFA-1, but not anti-VLA-4 treatment, all vaccinated mice displayed increased blood and tissue parasitemia, and quickly succumbed to infection. In addition, there was an accumulation of specific CD8+T cells in the spleen and lymph nodes and a decrease in the number of those cells, especially in the heart, suggesting that LFA-1 is important for the output of specific CD8+T cells from secondary lymphoid organs into infected organs such as the heart. The treatment did not alter CD8+T cell effector functions such as the production of pro-inflammatory cytokines and granzyme B, and maintained the proliferative capacity after treatment. However, the specific CD8+T cell direct cytotoxicity was impaired after LFA-1 blockade. Also, these cells expressed higher levels of Fas/CD95 on the surface, suggesting that they are susceptible to programmed cell death by the extrinsic pathway. We conclude that LFA-1 plays an important role in the migration of specific CD8+T cells and in the direct cytotoxicity of these cells. | pt_BR |
Affilliation | Centro de Terapia Molecular e Celular. Laboratório de Imunologia Molecular. São Paulo, SP, Brasil / Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Centro de Terapia Molecular e Celular. Laboratório de Imunologia Molecular. São Paulo, SP, Brasil / Universidade Federal de São Paulo. Departamento de Biociências. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Centro de Terapia Molecular e Celular. Laboratório de Imunologia Molecular. São Paulo, SP, Brasil / Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Centro de Terapia Molecular e Celular. Laboratório de Imunologia Molecular. São Paulo, SP, Brasil / Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Biociências. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil / University of Massachusetts Medical School. Department of Medicine. Division of Infectious Disease and Immunology. Worcester, MA, USA. | pt_BR |
Affilliation | Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Florianópolis, SC, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Biociências. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Departamento de Biociências. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Centro de Terapia Molecular e Celular. Laboratório de Imunologia Molecular. São Paulo, SP, Brasil / Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil / Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Centro de Terapia Molecular e Celular. Laboratório de Imunologia Molecular. São Paulo, SP, Brasil / Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil / Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil / Universidade Federal de São Paulo. Departamento de Biociências. São Paulo, SP, Brasil. | pt_BR |
Subject | vaccination | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | migration | pt_BR |
Subject | integrins | pt_BR |
Subject | specific CD8+ T cells | pt_BR |