Author | Andrade, Bruno de Bezerril | |
Author | Hullsiek, Katherine Huppler | |
Author | Boulware, David R | |
Author | Rupert, Adam | |
Author | French, Martyn A | |
Author | Ruxrungtham, Kiat | |
Author | Montes, Marisa Luisa | |
Author | Price, Huw | |
Author | Barreiro, Pablo | |
Author | Audsley, Jennifer | |
Author | Sher, Alan | |
Author | Lewin, Sharon R | |
Author | Sereti, Irini | |
Access date | 2018-02-20T12:34:27Z | |
Available date | 2018-02-20T12:34:27Z | |
Document date | 2013 | |
Citation | ANDRADE, B.B. et al. Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses. The Journal of Infectious Diseases, v. 207, p. 1379–1388, 2013. | pt_BR |
ISSN | 0022-1899 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24875 | |
Description | ANDRADE, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.documento”. | pt_BR |
Sponsorship | National Institute of Allergy and Infectious Diseases (NIAID; grants 3 U01 AI068641-05S1, U01AI042170, and U01AI046362) and the NIAID Intramural Research Program, National Institutes of Health; the National Research University Project of CHE and the Ratchadaphiseksomphot Endowment Fund, Thailand (grant HR1161A to K. R.); the National Science and Technology Development Agency, BIOTEC (grant to K. R.);
and the Thai Research Fund, Thailand (to K. R.). | pt_BR |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Vírus da hepatite | pt_BR |
Subject in Portuguese | Biomarcadores | pt_BR |
Subject in Portuguese | AIDS | pt_BR |
Subject in Portuguese | Hepatite | pt_BR |
Title | Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/infdis/jit033 | |
Abstract | Hepatitis C virus (HCV) and/or hepatitis B virus (HBV) coinfection with human immunodeficiency virus (HIV) has a greater risk of mortality than either HCV or HBV infection alone and is frequently associated with hepatitis flares after antiretroviral therapy (ART) initiation. Methods. We performed a retrospective cohort study of 287 HIV-positive persons coinfected with HBV and/
or HCV (70 had HBV coinfection only, 207 had HCV coninfection only, and 10 had HBV and HCV coinfections)
who had pre-ART plasma samples evaluated for biomarkers associated with death (within 4 years) and/or hepatitis
flare (within 4 months) after ART initiation. A predictive biomarker risk score was calculated.
Results. Forty-eight deaths and 50 hepatitis flares occurred. Nonsurvivors were older, had more prior AIDSdefining
events, and had higher pre-ART triglycerides and aspartate transaminase levels. Detectable hyaluronic
acid and higher D-dimer, interleukin 6, interleukin 8, and soluble CD14 levels were associated with death in univariate
models and with a composite biomarker risk score. The risk of hepatitis flares was higher with HBV
coinfection only (24.3%) and with HBV and HCV coinfection (50%) than with HCV coinfection only (13.5%).
Higher levels of alanine transaminase and interleukin 10 were also associated with hepatitis flares.
Conclusions. Among HIV-positive patients coinfected with HBV and/or HCV who are initiating ART, biomarkers
of inflammation and coagulation are associated with an increased risk of death, whereas HBV coinfection
and higher pre-ART interleukin 10 levels are associated with hepatitis flares. | pt_BR |
Affilliation | National Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD | pt_BR |
Affilliation | University of Minnesota. Minneapolis, MN, EUA | pt_BR |
Affilliation | University of Minnesota. Minneapolis, MN, EUA | pt_BR |
Affilliation | National Cancer Institute. SAIC Frederick. Frederick, MD, EUA | pt_BR |
Affilliation | University of Western Australia. Perth, Australia | pt_BR |
Affilliation | Chulalongkorn University. Faculty of Medicine. Bangkok Thailand / Thai Red Cross AIDS Research Center. Bangkok Thailand | pt_BR |
Affilliation | Hospital La Paz. Madrid, Spain | pt_BR |
Affilliation | Clinical Trials Unit. London, United Kingdom | pt_BR |
Affilliation | Hospital Carlos III. Madrid, Spain | pt_BR |
Affilliation | The Alfred Hospital. Melbourne, Australia / Monash University. Melbourne, Australia | pt_BR |
Affilliation | National Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, USA | pt_BR |
Affilliation | The Alfred Hospital. Melbourne, Australia / Monash University. Melbourne, Australia / Burnet Institute. Melbourne, Australia | pt_BR |
Affilliation | National Institute of Allergy Infectious Diseases. National Institutes of Health. Clinical and Molecular Retrovirology Section. Laboratory of Immunoregulation. Bethesda, MD | pt_BR |
Subject | Hepatic flares | pt_BR |
Subject | Biomarkers | pt_BR |
Subject | AIDS | pt_BR |
Subject | Hepatitis | pt_BR |