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https://www.arca.fiocruz.br/handle/icict/24818
THE DUAL ANTIOXIDANT/PROOXIDANT EFFECT OF EUGENOL AND ITS ACTION IN CANCER DEVELOPMENT AND TREATMENT
Metabolismo
Atividade antitumoral
Atividade antioxidante
Fenilpropanóide
Produtos naturais
Óleos essenciais
Dente de alho
Syzygium aromaticum
Metabolism
Antitumor activity
Antioxidant activity
Phenylpropanoid
Natural products
Essential oils
Clove
Syzygium aromaticum
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de Pernambuco. Departamento de Fisiologia. Recife, PE, Brasil
Universidade Federal da Paraíba. Departamento de Ciências Farmacêuticas. João Pessoa, PB, Brasil
Universidade Federal da Paraíba. Departamento de Ciências Farmacêuticas. João Pessoa, PB, Brasil
Universidade Federal de Pernambuco. Departamento de Fisiologia. Recife, PE, Brasil
Universidade Federal da Paraíba. Departamento de Ciências Farmacêuticas. João Pessoa, PB, Brasil
Universidade Federal da Paraíba. Departamento de Ciências Farmacêuticas. João Pessoa, PB, Brasil
Abstract
The formation of reactive oxygen species (ROS) during metabolism is a normal process usually compensated for by the antioxidant defense system of an organism. However, ROS can cause oxidative damage and have been proposed to be the main cause of age-related clinical complications and diseases such as cancer. In recent decades, the relationship between diet and cancer has been more studied, especially with foods containing antioxidant compounds. Eugenol is a natural compound widely found in many aromatic plant species, spices and foods and is used in cosmetics and pharmaceutical products. Eugenol has a dual effect on oxidative stress, which can action as an antioxidant or prooxidant agent. In addition, it has anti-carcinogenic, cytotoxic and antitumor properties. Considering the importance of eugenol in the area of food and human health, in this review, we discuss the role of eugenol on redox status and its potential use in the treatment and prevention of cancer.
Keywords in Portuguese
Especies de oxigênio reativasMetabolismo
Atividade antitumoral
Atividade antioxidante
Fenilpropanóide
Produtos naturais
Óleos essenciais
Dente de alho
Syzygium aromaticum
Keywords
Reactive oxygen speciesMetabolism
Antitumor activity
Antioxidant activity
Phenylpropanoid
Natural products
Essential oils
Clove
Syzygium aromaticum
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