Author | Andrade, Bruno de Bezerril | |
Author | Pavan Kumar, Nathella | |
Author | Mayer-Barber, Katrin D | |
Author | Barber, Daniel L | |
Author | Sridhar, Rathinam | |
Author | Rekha, Vaithilingam V Banu | |
Author | Jawahar, Mohideen S | |
Author | Nutman, Thomas B | |
Author | Sher, Alan | |
Author | Babu, Subash | |
Access date | 2018-02-06T16:41:32Z | |
Available date | 2018-02-06T16:41:32Z | |
Document date | 2013 | |
Citation | ANDRADE, B. B. et al. Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease. Plos One, v. 8, n. 5, p. e62618, 2013. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24743 | |
Description | Andrade, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health | pt_BR |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Tuberculose Pulmonar | pt_BR |
Subject in Portuguese | Heme Oxigenase-1 | pt_BR |
Subject in Portuguese | Tuberculose Latente | pt_BR |
Subject in Portuguese | Agentes antituberculosos | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Subject in Portuguese | Adolescente | pt_BR |
Title | Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0062618 | |
Abstract | Tuberculosis (TB) is associated with oxidative stress and the induction of host anti-oxidants to counteract this response. Heme oxygenase-1 (HO-1) is a critical promoter of cytoprotection in diverse disease models including mycobacterial infection. Nevertheless, the pattern of expression of HO-1 in human tuberculosis has not been studied. Here, we examine expression of HO-1 in M. tuberculosis-exposed and -infected individuals and test its ability to distinguish active from latent and successfully treated TB cases. In addition, we assess correlations between plasma levels of HO-1 and cytokines closely associated with the immunopathogenesis of TB. Methods: Cross-sectional and longitudinal analyses of levels of HO-1, acute phase proteins and pro-inflammatory cytokines
were performed in plasma samples from individuals with active pulmonary, extra-pulmonary or latent TB infection and
healthy controls as part of a prospective cohort study in South India.
Results: Systemic levels of HO-1 were dramatically increased in individuals with active pulmonary and extra-pulmonary
tuberculosis and particularly those with bilateral lung lesions and elevated bacillary loads in sputum. HO-1 levels effectively
discriminated active from latent tuberculosis with higher predictive values than either C-reactive protein or serum amyloid
protein. Moreover, there was a marked reduction in HO-1 levels in active TB cases following anti-tuberculous therapy but
not in those who failed treatment. Pulmonary TB patients displaying the highest concentrations of HO-1 in plasma exhibited
significantly elevated plasma levels of interleukin (IL)-10, interferon (IFN)-c and IL-17 and diminished levels of tumor necrosis
factor (TNF)-a.
Conclusion: These findings establish HO-1 levels as a potentially useful parameter for distinguishing active from latent or
treated pulmonary tuberculosis, that is superior in this respect to the measurement of other acute inflammatory proteins | pt_BR |
Affilliation | National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, United States of America | pt_BR |
Affilliation | National Institutes of Health. International Center for Excellence in Research. Chennai, India | pt_BR |
Affilliation | National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, United States of America | pt_BR |
Affilliation | National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, United States of America | pt_BR |
Affilliation | Government Stanley Medical Hospital., Chennai, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, United States of America | pt_BR |
Affilliation | National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, United States of America | pt_BR |
Affilliation | National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, United States of America / National Institutes of Health. International Center for Excellence in Research. Chennai, India / National Cancer Institute. Science Applications International Corporation. Frederick, Maryland, United States of America | pt_BR |
Subject | Tuberculosis, Pulmonary | pt_BR |
Subject | Heme Oxygenase-1 | pt_BR |
Subject | Latent Tuberculosis | pt_BR |
Subject | Antitubercular Agents | pt_BR |
Subject | Humans | pt_BR |
Subject | Adolescent | pt_BR |