Author | Freitas, Felipe | |
Author | Estato, Vanessa | |
Author | Reis, Patricia Alves | |
Author | Faria Neto, Hugo C. Castro | |
Author | Carvalho, Vinícius | |
Author | Torres, Rafael | |
Author | Lessa, Marcos A. | |
Author | Tibiriçá, Eduardo | |
Access date | 2018-01-16T14:47:04Z | |
Available date | 2018-01-16T14:47:04Z | |
Document date | 2017 | |
Citation | FREITAS, Felipe; et al. Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II-induced microcirculatory changes in a model of primary hypertension. Microcirculation, v.24, e12416, 12p, 2017. | pt_BR |
ISSN | 1073-9688 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/23926 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Microscopia Intravital | pt_BR |
Subject in Portuguese | Inibidores de Hidroximetilglutaril-CoA Redutases | pt_BR |
Subject in Portuguese | Efeitos Peliotropicos | pt_BR |
Subject in Portuguese | rarefação microvascular | pt_BR |
Subject in Portuguese | Imagens de contraste com manchas de laser | pt_BR |
Subject in Portuguese | sistema renina-angiotensina | pt_BR |
Title | Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II-induced microcirculatory changes in a model of primary hypertension | pt_BR |
Type | Article | |
DOI | 10.1111/micc.12416 | |
Abstract | Objective: We investigated the acute effects of SIM on cerebral microvascular rarefaction
and dysfunction in SHRs.
Methods: Male WKY and SHRs were divided into 4 groups of 8 animals each: WKY-CTL
and SHR-CTL,
treated with 0.9% saline; and WKY+SIM and SHR+SIM, treated
with SIM (30 mg/kg/d) for 3 days by gavage. Cerebral FCD was assessed by intravital
fluorescence videomicroscopy. mCBF before and after administration within the cranial
window of angiotensin II (1 μmol L−1) was investigated using laser speckle contrast
imaging.
Results: Cerebral FCD was reduced in SHR-CTL
compared to WKY-CTL
(P < .05). SIM
increased cerebral FCD in SHRs compared to SHR-CTL
(P < .05). The mCBF was reduced
in SHR-CTL
compared to WKY-CTL
(P < .05), and SIM increased mCBF compared
with SHR-CTL
(P < .05). Angiotensin II elicited a reduction of mCBF in SHR-CTL
and increased mCBF in WKY-CTL
(SHR-CTL
-13.53
± 2% vs WKY-CTL
+13.74 ± 4%;
P < .001), which was attenuated in SHRs treated with SIM (SHR+SIM -6.7
± 1% vs
SHR-CTL
-13.53
± 2%; P < .01).
Conclusions: The antihypertensive effect of SIM is associated with an improvement in
cerebral microvascular perfusion and capillary density that may help to prevent
hypertension-induced
cerebrovascular damage independent of cholesterol-lowering. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Estácio de Sá. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | intravital microscopy | pt_BR |
Subject | laser speckle contrast imaging | pt_BR |
Subject | microvascular rarefaction | pt_BR |
Subject | pleiotropic effects | pt_BR |
Subject | renin-angiotensin system | pt_BR |
Subject | statins | pt_BR |
e-ISSN | 1549-8719 | |
Embargo date | 2030-01-01 | |