Author | Mendonça, Vitor Rosa Ramos de | |
Author | Andrade, Bruno de Bezerril | |
Author | Souza, Ligia Correia Lima de | |
Author | Garcia, Gabriela Barreto Caldas | |
Author | Queiroz, Artur Trancoso Lopo de | |
Author | Gonçalves, Marilda de Souza | |
Author | Barral Netto, Manoel | |
Access date | 2017-12-27T14:32:24Z | |
Available date | 2017-12-27T14:32:24Z | |
Document date | 2012 | |
Citation | MENDONÇA, V. R. R. M. et al. Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/23786 | |
Language | eng | pt_BR |
Publisher | Sociedade Brasileira de Medicina Tropical | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Malária | pt_BR |
Subject in Portuguese | Mutações | pt_BR |
Subject in Portuguese | Gene | pt_BR |
Subject in Portuguese | Volume plasmático | pt_BR |
Subject in Portuguese | Proteínas | pt_BR |
Title | Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria | pt_BR |
Type | Papers presented at events | pt_BR |
Abstract | Introduction: During malaria, intense inflammation results in oxidative stress, and superoxide anions are the main reactive oxygen species produced. Cu/Zn superoxide dismutase (SOD1) is a key enzyme that, in together with catalase and glutathione peroxidase, scavenges superoxide anions and protects cells from oxidative damage. We have previously shown that SOD1 plasma levels are elevated in vivax malaria and that this enzyme can be used as a reliable biomarker for severe disease. Here, we test whether mutations in SOD1 gene (exon 1) and a Single Nucleotide Polymorphism (SNP) -308 (G>A) in the TNFalpha gene are associated with susceptibility to vivax malaria. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | National Institute of Allergy and Infectious Diseases National Institutes of Health. Laboratory of Parasitic Diseases,Immunobiology Section. Bethesda, MD, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. São Paulo, SP, Brasil. | pt_BR |
Subject | Malaria | pt_BR |
Subject | Mutation | pt_BR |
Subject | Gene | pt_BR |
Subject | Plasma volume | pt_BR |
Subject | Protein | pt_BR |