Author | Cruz, Heidi Lacerda Alves da | |
Author | Silva, Ronaldo Celerino da | |
Author | Segat, Ludovica | |
Author | Carvalho, Márcia Schneider Zuzarte de Mendonça Gomes de | |
Author | Brandão, Lucas André Cavalcanti | |
Author | Guimarães, Rafael Lima | |
Author | Santos, Fabiana Cristina Fulco | |
Author | Lira, Laís Ariane Siqueira de | |
Author | Montenegro, Lilian Maria Lapa | |
Author | Schindler, Haiana Charifker | |
Author | Crovella, Sergio | |
Access date | 2017-12-14T12:46:20Z | |
Available date | 2017-12-14T12:46:20Z | |
Document date | 2013 | |
Citation | CRUZ, H. L. A. da et al. MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population. Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, v. 19, p. 323–329, out. 2013. | pt_BR |
ISSN | 1567-7257 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/23657 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Tuberculose | pt_BR |
Subject in Portuguese | Imunidade inata | pt_BR |
Subject in Portuguese | MBL2 | pt_BR |
Subject in Portuguese | Pulmonar | pt_BR |
Subject in Portuguese | Polimorfismos | pt_BR |
Title | MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.meegid.2013.03.002 | |
Abstract | The innate immune system represents the first line of host defense against pathogens. Genetics factors regulating the immune responses play a role in the susceptibility to infectious diseases, such as tuberculosis (TB). We analyzed MBL2 promoter and exon 1 functional single nucleotide polymorphisms (SNPs) in a group of 155TB patients and 148 healthy controls in order to evaluate their influence on the onset of infection and TB development. There was no association between MBL2 -550 HL promoter polymorphisms and susceptibility to develop TB, but heterozygous -221 Y/X genotype was significantly more frequent in pulmonary TB patients than controls. Moreover, MBL2 exon 1 O allele, was significantly associated with susceptibility to TB development in general (p=0.023, OR=1.61, 95% CI 1.05-2.49) and pulmonary TB (p=0.0008, OR=2.16, 95% CI 1.35-3.46); C allele at codon 57, as well as A/C genotype, were significantly more frequent in TB patients than in controls. Our results indicate that MBL2 polymorphisms, especially at codon 57, could be considered as risk factors for TB development. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil / Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Recife, PE, Brazil. | pt_BR |
Affilliation | Institute for Maternal and Child Health. Trieste, Italy. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil / Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil. | pt_BR |
Affilliation | Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Recife, PE, Brazil / Federal University of Pernambuco. Department of Pathology. Recife, PE, Brazil. | pt_BR |
Affilliation | Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil / Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Recife, PE, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Institute for Maternal and Child Health. Trieste, Italy. | pt_BR |
Subject | Tuberculosis | pt_BR |
Subject | Innate immunity | pt_BR |
Subject | MBL2 | pt_BR |
Subject | Pulmonary | pt_BR |
Subject | Polymorphisms | pt_BR |
DeCS | Predisposição Genética para Doença | pt_BR |
DeCS | genética | pt_BR |
DeCS | Lectina de Ligação a Manose | pt_BR |
DeCS | genética | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | epidemiologia | pt_BR |
DeCS | Estudos de Casos e Controles | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Genótipo | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Polimorfismo de Nucleotídeo Único | pt_BR |
DeCS | genética | pt_BR |
DeCS | Tuberculose Pulmonar | pt_BR |
DeCS | epidemiologia | pt_BR |
DeCS | Tuberculose Pulmonar | pt_BR |
DeCS | genética | pt_BR |
DeCS | Adulto Jovem | pt_BR |