Author | Douradinha, Bruno | |
Author | McBurney, Sean P. | |
Author | Melo, Klecia M. Soares de | |
Author | Smith, Amanda P. | |
Author | Krishna, Neel K. | |
Author | Barratt-Boyes, Simon M. | |
Author | Evans, Jared D. | |
Author | Nascimento, Eduardo J. M. | |
Author | Marques, Ernesto T. A. | |
Access date | 2017-12-11T13:34:26Z | |
Available date | 2017-12-11T13:34:26Z | |
Document date | 2014 | |
Citation | DOURADINHA, B. et al. C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells. Virus Research, v. 179, p. 231–234, jan. 2014. | pt_BR |
ISSN | 1872-7492 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/23599 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Dengue | pt_BR |
Subject in Portuguese | Febre Hemorrágica da Dengue | pt_BR |
Subject in Portuguese | Febre de Dengue | pt_BR |
Subject in Portuguese | C1q | pt_BR |
Subject in Portuguese | Caminho de Complemento Clássico | pt_BR |
Subject in Portuguese | Persistência Viral | pt_BR |
Title | C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.virusres.2013.11.007 | |
Abstract | Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in severe dengue. Screening of complement proteins demonstrated that C1q, a pattern recognition molecule, can bind directly to dengue virus envelope protein and to whole dengue virus serotype 2. Incubation of dengue virus serotype 2 with C1q prior to infection of THP-1 cells led to decreased virus infectivity and modulation of mRNA expression of immunoregulatory molecules suggesting reduced inflammatory responses. | pt_BR |
Affilliation | Fondazione Ri.MED. Palermo, Italy / University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA. | pt_BR |
Affilliation | University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA. | pt_BR |
Affilliation | University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
Affilliation | University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA. | pt_BR |
Affilliation | Eastern Virginia Medical School. Department of Microbiology and Molecular Cell Biology. Norfolk, Virginia, USA. | pt_BR |
Affilliation | University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / University of Pittsburgh. Graduate School of Public Health. Department of Infectious Diseases and Microbiology. Pittsburgh, USA. | pt_BR |
Affilliation | University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / University of Pittsburgh. School of Medicine. Department of Microbiology and Molecular Genetics. Pittsburgh, USA. | pt_BR |
Affilliation | University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / University of Pittsburgh. Graduate School of Public Health. Department of Infectious Diseases and Microbiology. Pittsburgh, USA. | pt_BR |
Affilliation | University of Pittsburgh. Center for Vaccine Research. Pittsburgh, USA / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / University of Pittsburgh. Graduate School of Public Health. Department of Infectious Diseases and Microbiology. Pittsburgh, USA. | pt_BR |
Subject | Dengue | pt_BR |
Subject | Dengue Hemorrhagic Fever | pt_BR |
Subject | Dengue Fever | pt_BR |
Subject | C1q | pt_BR |
Subject | Classical Complement Pathway | pt_BR |
Subject | Viral Persistence | pt_BR |
DeCS | Complemento C1q | pt_BR |
DeCS | metabolismo | pt_BR |
DeCS | Vírus da Dengue | pt_BR |
DeCS | fisiologia | pt_BR |
DeCS | Dengue | pt_BR |
DeCS | genética | pt_BR |
DeCS | Mediadores da Inflamação | pt_BR |
DeCS | imunologia | pt_BR |
DeCS | Antígenos CD14 | pt_BR |
DeCS | genética | pt_BR |
DeCS | Antígenos CD14 | pt_BR |
DeCS | imunologia | pt_BR |
DeCS | Antígenos CD86 | pt_BR |
DeCS | genética | pt_BR |
DeCS | Antígenos CD86 | pt_BR |
DeCS | imunologia | pt_BR |
DeCS | Moléculas de Adesão Celular | pt_BR |
DeCS | genética | pt_BR |
DeCS | Linhagem Celular | pt_BR |
DeCS | humanos | pt_BR |
DeCS | Complemento C1q | pt_BR |
DeCS | imunologia | pt_BR |
DeCS | Dengue | pt_BR |
DeCS | metabolismo | pt_BR |
DeCS | Dengue | pt_BR |
DeCS | virologia | pt_BR |
DeCS | Vírus da Dengue | pt_BR |
DeCS | classificação | pt_BR |
DeCS | Lectinas Tipo C | pt_BR |
DeCS | Ligação Proteica | pt_BR |
DeCS | Receptores de Superfície Celular | pt_BR |
DeCS | Proteínas do Envelope Viral | pt_BR |