Author | Chagas, Andrezza C. | |
Author | McPhie, Peter | |
Author | San, Hong | |
Author | Narum, David | |
Author | Reiter, Karine | |
Author | Tokomasu, Fuyuki | |
Author | Brayner, Fabio A. | |
Author | Alves, Luiz C. | |
Author | Ribeiro, José M. C. | |
Author | Calvo, Eric | |
Access date | 2017-11-23T13:36:24Z | |
Available date | 2017-11-23T13:36:24Z | |
Document date | 2014 | |
Citation | CHAGAS, A. C. et al. Simplagrin, a Platelet Aggregation Inhibitor from Simulium nigrimanum Salivary Glands Specifically Binds to the Von Willebrand Factor Receptor in Collagen and Inhibits Carotid Thrombus Formation In Vivo. PLoS Neglected Tropical Diseases, v. 8, n. 6, p. e2947, 12 jun. 2014. | pt_BR |
ISSN | 1935-2735 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/23318 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | glândulas salivares | pt_BR |
Subject in Portuguese | mosquitos | pt_BR |
Subject in Portuguese | moscas negras | pt_BR |
Subject in Portuguese | Inibidores | pt_BR |
Title | Simplagrin, a platelet aggregation inhibitor from Simulium nigrimanum salivary glands specifically binds to the Von Willebrand factor receptor in collagen and inhibits carotid thrombus formation in vivo | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pntd.0002947 | |
Abstract | Among the several challenges faced by bloodsucking arthropods, the vertebrate hemostatic response against blood loss represents an important barrier to efficient blood feeding. Here we report the first inhibitor of collagen-induced platelet aggregation derived from the salivary glands of a black fly (Simulium nigrimanum), named Simplagrin. | pt_BR |
Affilliation | Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland, United States of America. | pt_BR |
Affilliation | Physical and Biochemistry Section, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America. | pt_BR |
Affilliation | Animal Surgery and Resources Core, National Heart Lung and Blood Institute, NIH, Bethesda, Maryland, United States of America. | pt_BR |
Affilliation | Laboratory of Malaria Immunology and Vaccinology, NIAID, NIH, Bethesda, Maryland, United States of America. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil / Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. | pt_BR |
Subject | Salivary Glands | pt_BR |
Subject | mosquitoes | pt_BR |
Subject | black flies | pt_BR |
Subject | Inibidores | pt_BR |
DeCS | Proteínas de Insetos | pt_BR |
DeCS | metabolismo | pt_BR |
DeCS | Inibidores da Agregação de Plaquetas | pt_BR |
DeCS | metabolismo | pt_BR |
DeCS | Glicoproteínas da Membrana de Plaquetas | pt_BR |
DeCS | metabolismo | pt_BR |
DeCS | Glândulas Salivares | pt_BR |
DeCS | química | pt_BR |
DeCS | Simuliidae | pt_BR |
DeCS | metabolismo | pt_BR |
DeCS | Sequência de Aminoácidos | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Trombose das Artérias Carótidas | pt_BR |
DeCS | prevenção & controle | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Células HEK293 | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Camundongos Endogâmicos C57BL | pt_BR |
DeCS | Dados de Sequência Molecular | pt_BR |
DeCS | Adesividade Plaquetária | pt_BR |
DeCS | Agregação Plaquetária | pt_BR |
DeCS | Ligação Proteica Estrutura | pt_BR |
DeCS | Terciária de Proteína | pt_BR |