Author | Sardi, Silvia Ines | |
Author | Somasekar, Sneha | |
Author | Naccache, Samia N. | |
Author | Bandeira, Antonio Carlos de Albuquerque | |
Author | Tauro, Laura Beatriz | |
Author | Campos, Gubio Soares | |
Author | Chiu, Charles Y | |
Access date | 2017-10-10T16:44:17Z | |
Available date | 2017-10-10T16:44:17Z | |
Document date | 2016 | |
Citation | SARDI, Silvia Ines et al. Coinfections of Zika and Chikungunya Viruses in Bahia, Brazil, Identified by Metagenomic Next-Generation Sequencing. Journal of Clinical Microbiology, v. 54, n. 9, p. 2348-2353, 2016. | pt_BR |
ISSN | 0095-1137 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/22818 | |
Sponsorship | HHS National Institutes of Health (NIH) (R01-HL105704 and R21-AI120977). This work, including the efforts of Charles Y. Chiu, was funded by Abbott Laboratories. | pt_BR |
Language | eng | pt_BR |
Publisher | American Society for Microbiology | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Virus Zika | pt_BR |
Subject in Portuguese | Infecção por vírus Zika | pt_BR |
Subject in Portuguese | Febre Chikungunya | pt_BR |
Subject in Portuguese | Virus Chikungunya | pt_BR |
Subject in Portuguese | Infecção | pt_BR |
Subject in Portuguese | Metagenômica | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Subject in Portuguese | Adulto | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | Coinfections of Zika and Chikungunya Viruses in Bahia, Brazil, Identified by Metagenomic Next-Generation Sequencing | pt_BR |
Type | Article | pt_BR |
DOI | 10.1128/JCM.00877-16 | |
Abstract | Metagenomic next-generation sequencing (mNGS) of samples from 15 patients with documented Zika virus (ZIKV) infection in Bahia, Brazil, from April 2015 to January 2016 identified coinfections with chikungunya virus (CHIKV) in 2 of 15 ZIKV-positive cases by PCR (13.3%). While generally nonspecific, the clinical presentation corresponding to these two CHIKV/ZIKV coinfections reflected infection by the virus present at a higher titer. Aside from CHIKV and ZIKV, coinfections of other viral pathogens were not detected. The mNGS approach is promising for differential diagnosis of acute febrile illness and identification of coinfections, although targeted arbovirus screening may be sufficient in the current ZIKV outbreak setting. | pt_BR |
Affilliation | University Federal of Bahia. Health Institute of Science. Laboratory of Virology. Salvador, BA, Brazil. | pt_BR |
Affilliation | University of California. Department of Laboratory Medicine. San Francisco, California, USA / UCSF-Abbott Viral Diagnostics and Discovery Center. San Francisco, CA, USA. | pt_BR |
Affilliation | University of California. Department of Laboratory Medicine. San Francisco, California, USA / UCSF-Abbott Viral Diagnostics and Discovery Center. San Francisco, CA, USA. | pt_BR |
Affilliation | Aliança Hospital. Salvador, BA, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | University Federal of Bahia. Health Institute of Science. Laboratory of Virology. Salvador, BA, Brazil. | pt_BR |
Affilliation | University of California. Department of Laboratory Medicine. San Francisco, CA, USA / UCSF-Abbott Viral Diagnostics and Discovery Center. San Francisco, CA, USA / University of California,. Department of Medicine, Division of Infectious Diseases. San Francisco, CA, USA. | pt_BR |
Subject | Zika Virus | pt_BR |
Subject | Zika Virus Infection | pt_BR |
Subject | Chikungunya Fever | pt_BR |
Subject | Chikungunya virus | pt_BR |
Subject | Coinfection | pt_BR |
Subject | Metagenomics | pt_BR |
Subject | Humans | pt_BR |
Subject | Adult | pt_BR |
Subject | Brazil | pt_BR |