Author | Zanello, Paula Rodrigues | |
Author | Koishi, Andrea Cristine | |
Author | Rezende Júnior, Celso de Oliveira | |
Author | Oliveira, Larissa Albuquerque | |
Author | Pereira, Adriane Antonia | |
Author | Almeida, Mauro Vieira de | |
Author | Santos, Claudia Nunes Duarte dos | |
Author | Bordignon, Juliano | |
Access date | 2017-10-05T12:29:44Z | |
Available date | 2017-10-05T12:29:44Z | |
Document date | 2015 | |
Citation | ZANELLO, Paula Rodrigues et al. Quinic acid derivatives inhibit dengue virus replication in vitro. Virology Journal, v. 12, n. 223, p. 1-13, 2015. | pt_BR |
ISSN | 1743-422X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/22777 | |
Language | por | pt_BR |
Publisher | BioMed Central | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Dengue | pt_BR |
Title | Quinic acid derivatives inhibit dengue virus replication in vitro | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/s12985-015-0443-9 | |
Abstract | Dengue is the most prevalent arboviral disease in tropical and sub-tropical areas of the world. The incidence of infection is estimated to be 390 million cases and 25,000 deaths per year. Despite these numbers, neither a specific treatment nor a preventive vaccine is available to protect people living in areas of high risk. With the aim of seeking a treatment that can mitigate dengue infection, we demonstrated that the quinic acid derivatives known as compound 2 and compound 10 were effective against all four dengue virus serotypes and safe for use in a human hepatoma cell line (Huh7.5). Both compounds were non-virucidal to dengue virus particles and did not interfere with early steps of the dengue virus life cycle, including binding and internalization. Experiments using a replicon system demonstrated that compounds 2 and 10 impaired dengue virus replication in Huh7.5 cells. Additionally, the anti-dengue virus effects of the quinic acid derivatives were preserved in human peripheral blood mononuclear cells.Taken together, these data suggest that quinic acid derivatives represent a novel chemical class of active compounds that could be used to combat dengue virus infection. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Subject | Virus Replication | pt_BR |
Subject | Antiviral Agents | pt_BR |
Subject | Quinic Acid | pt_BR |
Subject in Spanish | Replicación Viral | pt_BR |
Subject in Spanish | Antivirales | pt_BR |
DeCS | Replicação Viral | pt_BR |
DeCS | Antivirais | pt_BR |
DeCS | Ácido Quínico | pt_BR |