Author | Amaral, Eduardo Pinheiro | |
Author | Andrade, Bruno de Bezerril | |
Access date | 2017-09-25T17:59:16Z | |
Available date | 2017-09-25T17:59:16Z | |
Document date | 2017 | |
Citation | AMARAL, E. P.; ANDRADE, B. B. Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection. Clinical Medicine Insights: Case Reports, v. 9, p. 1-10, 2017. | pt_BR |
ISSN | 1178-6450 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/21099 | |
Language | eng | pt_BR |
Publisher | Libertas Academica | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Mycobactérias | pt_BR |
Subject in Portuguese | Sensores | pt_BR |
Subject in Portuguese | NF-κappa B | pt_BR |
Subject in Portuguese | Hospedeiro | pt_BR |
Subject in Portuguese | Mycobacterium tuberculosis | pt_BR |
Title | Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection | pt_BR |
Type | Article | pt_BR |
Abstract | The interactions between pathogens and host cells and the way by which the immune response is modulated during this process
ultimately dictate the fate of infection. Host phagocytes exposed to Mycobacterium tuberculosis (M. tuberculosis) sense microbial-associated
molecular patterns and activate a series of signaling pathways. In this setting, activation of the nuclear factor κB (NF-κB) initiates transcription of
several key genes involved in orchestration of antimycobacterial effector functions. This review describes these major pathways that govern the
outcome of host phagocytes infected with M. tuberculosis. Furthermore, we highlight evidence of how M. tuberculosis modulates activation of
NF-κB pathways to evade the host antimycobacterial defense. | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, USA / University of São Paulo. Institute of Biomedical Sciences. Laboratory of Immunology of Infectious Diseases. Department of Immunology. São Paulo, SP, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil | pt_BR |
Subject | Mycobacteria | pt_BR |
Subject | Immune sensors | pt_BR |
Subject | NF-κB pathways | pt_BR |
Subject | Host defense | pt_BR |
Subject | Mycobacterium tuberculosis | pt_BR |