Author | Nye, Lynn | |
Author | Pontes-de-Carvalho, Lain Carlos | |
Author | Roitt, I. M | |
Access date | 2017-09-04T13:48:07Z | |
Available date | 2017-09-04T13:48:07Z | |
Document date | 1981 | |
Citation | NYE, L.; PNTES-DE-CARVALHO, L. C.; ROITT, I. M. CARVALHOAn investigation of the clonality of human autoimmune thyroglobulin antibodies and their light chains. Clinical an Experimental Immunology, v. 46, p. 161-170, 1981. | pt_BR |
ISSN | 0009-9104 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20898 | |
Description | Pontes-de-Carvalho, Lain Carlos “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnológico. | pt_BR |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Tireoglobulina | pt_BR |
Subject in Portuguese | Anticorpos | pt_BR |
Subject in Portuguese | Cromatografia de Afinidade | pt_BR |
Subject in Portuguese | Imunoglobulina | pt_BR |
Title | An investigation of the clonality of human autoimmune thyroglobulin antibodies and their light chains | pt_BR |
Type | Article | pt_BR |
Abstract | Thyroglobulin antibodies in the sera from 31 patients with a variety of disorders were
studied by isoelectric focusing. Only one gave a spectrotype indicative of a monoclonal
response, the other 30 giving spectrotypes characteristic of polyclonal responses. There
was evidence of clonal dominance in some of the sera and each gave a different
spectrotype. Light chains were prepared from five thyroglobulin antibodies purified by
affinity chromatography. There was no restriction in the spectrotypes when compared
with light chains prepared from normal immunoglobulin. | pt_BR |
Affilliation | Middlesex Hospital Medical School. Department of Immunology. London, USA | pt_BR |
Affilliation | Middlesex Hospital Medical School. Department of Immunology. London, USA | pt_BR |
Affilliation | Middlesex Hospital Medical School. Department of Immunology. London, USA | pt_BR |
Subject | Thyroglobulin | pt_BR |
Subject | Antibodies | pt_BR |
Subject | Affinity chromatography | pt_BR |
Subject | Immunoglobulin | pt_BR |