Author | Santos, Patrícia d'Emery Alves | |
Author | Lorena, Virgínia Maria Barros de | |
Author | Fernandes, Érica de Souza | |
Author | Sales, Iana Rafaela Fernandes | |
Author | Nascimento, Wheverton Ricardo Correia do | |
Author | Gomes, Yara de Miranda | |
Author | Albuquerque, Mônica Camelo Pessoa de Azevedo | |
Author | Costa, Vlaudia Maria Assis | |
Author | Souza, Valdênia Maria Oliveira de | |
Access date | 2017-09-01T13:58:39Z | |
Available date | 2017-09-01T13:58:39Z | |
Document date | 2016 | |
Citation | SANTOS, P. D’EMERY A. et al. Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection. Memorias Do Instituto Oswaldo Cruz, v. 111, n. 2, p. 83–92, fev. 2016. | pt_BR |
ISSN | 1678-8060 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20889 | |
Language | por | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Hepatopatias Parasitárias | pt_BR |
Subject in Portuguese | Granuloma de Corpo Estranho | pt_BR |
Subject in Portuguese | Anticorpos Anti-Helmínticos | pt_BR |
Subject in Portuguese | Schistosoma mansoni | pt_BR |
Subject in Portuguese | Animais Lactentes | pt_BR |
Subject in Portuguese | Schistosomiasis mansoni | pt_BR |
Subject in Portuguese | Animais Recém-Nascidos | pt_BR |
Title | Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-02760150293 | |
Abstract | Schistosoma mansoni antigens in the early life alter homologous and heterologous immunity during postnatal infections. We evaluate the immunity to parasite antigens and ovalbumin (OA) in adult mice born/suckled by schistosomotic mothers. Newborns were divided into: born (BIM), suckled (SIM) or born/suckled (BSIM) in schistosomotic mothers, and animals from noninfected mothers (control). When adults, the mice were infected and compared the hepatic granuloma size and cellularity. Some animals were OA + adjuvant immunised. We evaluated hypersensitivity reactions (HR), antibodies levels (IgG1/IgG2a) anti-soluble egg antigen and anti-soluble worm antigen preparation, and anti-OA, cytokine production, and CD4+FoxP3+T-cells by splenocytes. Compared to control group, BIM mice showed a greater quantity of granulomas and collagen deposition, whereas SIM and BSIM presented smaller granulomas. BSIM group exhibited the lowest levels of anti-parasite antibodies. For anti-OA immunity, immediate HR was suppressed in all groups, with greater intensity in SIM mice accompanied of the remarkable level of basal CD4+FoxP3+T-cells. BIM and SIM groups produced less interleukin (IL)-4 and interferon (IFN)-g. In BSIM, there was higher production of IL-10 and IFN-g, but lower levels of IL-4 and CD4+FoxP3+T-cells. Thus, pregnancy in schistosomotic mothers intensified hepatic fibrosis, whereas breastfeeding diminished granulomas in descendants. Separately, pregnancy and breastfeeding could suppress heterologous immunity; however, when combined, the responses could be partially restored in infected descendants. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil | pt_BR |
Subject | Granuloma, Foreign-Body | pt_BR |
Subject | Liver Diseases, Parasitic | pt_BR |
Subject | Schistosoma mansoni | pt_BR |
Subject | Animals, Suckling | pt_BR |
Subject | Adjuvants, Immunologic | pt_BR |
Subject | Animals | pt_BR |
Subject | Animals, Newborn | pt_BR |
Subject | Antibodies, Helminth | pt_BR |
Subject | CD4-Positive T-Lymphocytes | pt_BR |
Subject | Cercaria | pt_BR |
Subject | Enzyme-Linked Immunosorbent Assay | pt_BR |
Subject | Female | pt_BR |
Subject | Flow Cytometry | pt_BR |
Subject | Forkhead Transcription Factors | pt_BR |
Subject | Immunity, Heterologous | pt_BR |
Subject | Immunity, Humoral | pt_BR |
Subject | Immunoglobulin G | pt_BR |
Subject | Interferon-gamma | pt_BR |
Subject | Interleukin-4 | pt_BR |
Subject | Interleukin-10 | pt_BR |
Subject | Liver Cirrhosis | pt_BR |
Subject | Male | pt_BR |
Subject | Mice | pt_BR |
Subject | Mothers | pt_BR |
Subject | Ovalbumin | pt_BR |
Subject | Pregnancy | pt_BR |
Subject | Schistosomiasis mansoni | pt_BR |
Subject | Spleen | pt_BR |
DeCS | Anticorpos Anti-Helmínticos | pt_BR |
DeCS | Hepatopatias Parasitárias | pt_BR |
DeCS | Granuloma de Corpo Estranho | pt_BR |
DeCS | Schistosoma mansoni | pt_BR |
DeCS | Animais Lactentes | pt_BR |
DeCS | Esquistossomose mansoni | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Mães | pt_BR |
DeCS | Gravidez | pt_BR |
DeCS | Ovalbumina | pt_BR |
DeCS | Baço | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Cirrose Hepática | pt_BR |
DeCS | Interleucina-4 | pt_BR |
DeCS | Interleucina-10 | pt_BR |
DeCS | Interferon gama | pt_BR |
DeCS | Imunoglobulina G | pt_BR |
DeCS | Imunidade Humoral | pt_BR |
DeCS | Imunidade Heteróloga | pt_BR |
DeCS | Fatores de Transcrição Forkhead | pt_BR |
DeCS | Citometria de Fluxo | pt_BR |
DeCS | Ensaio de Imunoadsorção Enzimática | pt_BR |
DeCS | Cercaria | pt_BR |
DeCS | Linfócitos T CD4-Positivos | pt_BR |
DeCS | Animais Recém-Nascidos | pt_BR |
DeCS | Adjuvantes Imunológicos | pt_BR |