Author | Fontes, José Eraldo do Nascimento | |
Author | Ferraz, Rosana Paula Cruz | |
Author | Britto, Anny Caroline Siqueira | |
Author | Carvalho, Adriana Andrade | |
Author | Moraes, Manoel O | |
Author | Pessoa, Claudia do Ó | |
Author | Costa, Emmanoel Vilaça | |
Author | Bezerra, Daniel Pereira | |
Access date | 2017-08-23T18:14:51Z | |
Available date | 2017-08-23T18:14:51Z | |
Document date | 2013 | |
Citation | FONTES, J. E. N. et al. Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae). Chemistry and Biodiversity, v. 10, p. 722-729, 2013. | pt_BR |
ISSN | 1612-1872 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20720 | |
Description | Bezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | (Coordenadoria de Apoio a Pesquisa e Ensino Superior), CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnológico), FUNCAP (Fundação Cearense de Apoio ao Desenvolvimento Cientí fico e Tecnológico), and FAPITEC/SE (Fundação de Amparo à Pesquisa e à Inovação Tecnológica do Estado de Sergipe). | pt_BR |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Sarcoma | pt_BR |
Subject in Portuguese | Tumor | pt_BR |
Subject in Portuguese | Neoplasias | pt_BR |
Subject in Portuguese | Transplante | pt_BR |
Subject in Portuguese | Folhas de plantas | pt_BR |
Subject in Portuguese | Óleos | pt_BR |
Subject in Portuguese | Ratos | pt_BR |
Title | Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae) | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/cbdv.201200304 | |
Abstract | Guatteria pogonopus Martius, a plant belonging to the Annonaceae family, is found in the remaining Brazilian Atlantic Forest. In this study, the chemical composition and antitumor effects of the essential oil isolated from leaves of G. pogonopus was investigated. The chemical composition of the oil was determined by GC-FID and GC/MS analyses. The in vitro cytotoxicity was evaluated against three different tumor cell lines (OVCAR-8, NCI-H358M, and PC-3M), and the in vivo antitumor activity was tested in mice bearing sarcoma 180 tumor. A total of 29 compounds was identified and quantified in the oil. The major compounds were γ-patchoulene (13.55%), (E)-caryophyllene (11.36%), β-pinene (10.37%), germacrene D (6.72%), bicyclogermacrene (5.97%), α-pinene (5.33%), and germacrene B (4.69%). The essential oil, but neither (E)-caryophyllene nor β-pinene, displayed in vitro cytotoxicity against all three tumor cell lines tested. The obtained average IC50 values ranged from 3.8 to 20.8 μg/ml. The lowest and highest values were obtained against the NCI-H358M and the OVCAR-8 cell lines, respectively. The in vivo tumor-growth-inhibition rates in the tumor-bearing mice treated with essential oil (50 and 100 mg/kg/d) were 25.3 and 42.6%, respectively. Hence, the essential oil showed significant in vitro and in vivo antitumor activity. | pt_BR |
Affilliation | Federal University of Sergipe. Department of Chemistry. São Cristóvão. Aracaju, SE, Brazil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão. Aracaju, SE, Brazil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão. Aracaju, SE, Brazil | pt_BR |
Affilliation | Federal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil | pt_BR |
Affilliation | Federal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil | pt_BR |
Affilliation | Federal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Chemistry. São Cristóvão. Aracaju, SE, Brazil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão. Aracaju, SE, Brazil | pt_BR |
Subject | Sarcoma | pt_BR |
Subject | Cell Line, Tumor | pt_BR |
Subject | Neoplasms | pt_BR |
Subject | Transplantation, Heterologous | pt_BR |
Subject | Plant Leaves | pt_BR |
Subject | Oils, Volatile | pt_BR |
Subject | Mice | pt_BR |