Author | Menezes, Leociley Rocha Alencar | |
Author | Santos, Nilmara Nunes | |
Author | Meira, Cássio Santana | |
Author | Santos, Jamyle Andrade Ferreira dos | |
Author | Guimarães, Elisalva Teixeira | |
Author | Soares, Milena Botelho Pereira | |
Author | Nepel, Angelita | |
Author | Barison, Andersson | |
Author | Costa, Emmanoel Vilaça | |
Access date | 2017-08-17T17:17:45Z | |
Available date | 2017-08-17T17:17:45Z | |
Document date | 2014 | |
Citation | MENEZES, R. L. A. et al. A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties. Natural Product Communications, v. 9, n. 6, p. 737-739, 2014. | pt_BR |
ISSN | 1934-578X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20671 | |
Sponsorship | FAPITEC/SE (Editais No 07/2009 and 10/2009), FAPESB, CNPq, FINEP, UFPR and CAPES | pt_BR |
Language | eng | pt_BR |
Publisher | Natural Product Incorporation | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Lippia pedunculosa | pt_BR |
Subject in Portuguese | Óleo essencial | pt_BR |
Subject in Portuguese | Atividade tripanocida | pt_BR |
Subject in Portuguese | Monoterpenos | pt_BR |
Subject in Portuguese | Limoneno | pt_BR |
Subject in Portuguese | Rotundifolia | pt_BR |
Title | A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties | pt_BR |
Type | Article | pt_BR |
Abstract | Investigation by GC-FID and GC-MS of the essential oil (LPOE) from the leaves of Lippia pedunculosa revealed, as the major compounds, the monoterpenes
rotundifolone (71.7%) and (R)-limonene (21.8%). These two compounds and the minor constituent piperitenone (1.2%) were also isolated from the leaves and
identified by spectrometric analysis. LPOE and isolated compounds were evaluated for their trypanocidal activity against epimastigote and trypomastigote
forms of Trypanosoma cruzi. Significant results with IC50 values lower than 34.0 g.mL-1 were observed against these forms of T. cruzi for LPOE and isolated
compounds. Rotundifolone was the most active compound with an IC50 lower than 10.0 g.mL-1 for both forms of T. cruzi. The effects of LPOE and isolated
compounds were also evaluated in cultures of macrophages infected with T. cruzi. Treatment with (R)-limonene and rotundifolone caused a moderate reduction
in the percentage of macrophages infected by T. cruzi and in the number of intracellular parasites at concentrations non-toxic to macrophages. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal do Paraná. Departamento de Química. Curitiba, PR, Brasil | pt_BR |
Affilliation | Universidade Federal do Paraná. Departamento de Química. Curitiba, PR, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Química. Itabaiana, SE, Brasil | pt_BR |
Subject | Lippia pedunculosa | pt_BR |
Subject | Essential oil | pt_BR |
Subject | Trypanocidal activity | pt_BR |
Subject | Monoterpenes | pt_BR |
Subject | Limonene | pt_BR |
Subject | Rotundifolone | pt_BR |