Author | Santos, Tássia L A dos | |
Author | Queiroz, Raphael F | |
Author | Sawaya, Alexandra Christine Helena Frankland | |
Author | Lopez, Begoña Gimenez-Cassina | |
Author | Soares, Milena Botelho Pereira | |
Author | Bezerra, Daniel Pereira | |
Author | Rodrigues, Ana Carolina B C | |
Author | Paula, Vanderlúcia Fonseca de | |
Author | Waldschmidt, Ana Maria | |
Access date | 2017-08-16T16:23:23Z | |
Available date | 2017-08-16T16:23:23Z | |
Document date | 2017 | |
Citation | SANTOS, T. L. A. dos et al. Melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities. Anais da Academia Brasileira de Ciências, jul. 2017. | pt_BR |
ISSN | 0001-3765 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20641 | |
Language | eng | pt_BR |
Publisher | Academia Brasileira de Ciências | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Antibacteriano | pt_BR |
Subject in Portuguese | Antioxidante | pt_BR |
Subject in Portuguese | Antiproliferativo | pt_BR |
Subject in Portuguese | Geopropolis | pt_BR |
Subject in Portuguese | Melipona mondury | pt_BR |
Title | Melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0001-3765201720160725 | |
Abstract | Geopropolis is a special type of propolis produced by stingless bees. Several pharmacological properties have been described for different types of geopropolis, but there have been no previous studies of the geopropolis from Melipona mondury. In this study, we investigated the antioxidant, antibacterial, and antiproliferative activities of M. mondury geopropolis, and determined its chemical profile. The antioxidant activity was determined using in vitro ABTS·+, ·DPPH, and β-carotene/linoleic acid co-oxidation methods. The antibacterial activity was determined using a microdilution method with Pseudomonas aeruginosa, Staphylococcus aureus, and methicillin-resistant S. aureus. The antiproliferative effect was determined in tumor cell lines using the Alamar Blue assay. The chemical profile was obtained using UHPLC-MS and UHPLC-MS/MS. The butanolic fraction had the highest concentration of phenolic compounds and more potent antioxidant properties in all assays. This fraction also had bacteriostatic and bactericidal effects against all bacterial strains at low concentrations, especially S. aureus. The hexane fraction had the highest antiproliferative potential, with IC50 values ranging from 24.2 to 46.6 µg/mL in HL-60 (human promyelocytic leukemia cell) and K562 (human chronic myelocytic leukemia cell), respectively. Preliminary chemical analysis indicates the presence of terpenes and gallic acid in the geopropolis. Our results indicate the therapeutic potential of geopropolis from M. mondury against inflammatory, oxidative, infectious, and neoplastic diseases. | pt_BR |
Affilliation | Universidade Estadual do Sudoeste da Bahia. Departamento de Ciências Biológicas. Jequié, BA, Brasil | pt_BR |
Affilliation | Universidade Estadual do Sudoeste da Bahia. Departamento de Ciências Naturais. Vitória da Conquista, BA, Brasil | pt_BR |
Affilliation | Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Biologia e Ciências Farmacêuticas. Campinas, SP, Brasil | pt_BR |
Affilliation | Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Biologia e Ciências Farmacêuticas. Campinas, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Estadual do Sudoeste da Bahia. Departmento de Química e Ciências Exatas. Jequié, BA, Brasil | pt_BR |
Affilliation | Universidade Estadual do Sudoeste da Bahia. Departamento de Ciências Biológicas. Jequié, BA, Brasil | pt_BR |
Subject | Antibacterial | pt_BR |
Subject | Antioxidant | pt_BR |
Subject | Antiproliferative | pt_BR |
Subject | Geopropolis | pt_BR |
Subject | Melipona mondury | pt_BR |