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https://www.arca.fiocruz.br/handle/icict/20605
LOCALIZED CUTANEOUS LEISHMANIASIS OF THE PLANTAR REGION: A 40-YEAR OUTCOME
Ulcera do pé
Hiperplasia epitelial
Reação em Cadeia da Polimerase
Humanos
Foot ulcer
Epithelial hyperplasia
Polymerase chain reaction
Humans
Author
Affilliation
Federal University of Rio Grande do Sul. Porto Alegre, RGS, Brazil
Lauro de Souza Lima Institute. Bauru, SP, Brasil
Lauro de Souza Lima Institute. Bauru, SP, Brasil
Federal and Catholic University of Pelotas. Pelotas, RGS, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Lauro de Souza Lima Institute. Bauru, SP, Brasil
Lauro de Souza Lima Institute. Bauru, SP, Brasil
Federal and Catholic University of Pelotas. Pelotas, RGS, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Abstract
We report the case of a 78-year-old male Brazilian farmer, who presented with an extensive ulcer on the right foot that had an erythematous and raised
border. This ulcer involved most of the right plantar region and had persisted for more than 40 years. Satellite erythematous papules and tumor-like growths
were also seen on the right ankle. Extracutaneous involvement was not found. Light microscopy showed epithelial hyperplasia and diffuse histiocyte infiltration
with intense plasmocytosis. Cultures for fungi and Leishmania were negative. The polymerase chain reaction with specific primers for Leishmania was
performed using DNA extracted from the lesions; it showed an amplification of 120 pB. The patient had an excellent response after two 20-day cycles of intravenous
N-methylglucamine antimonate (15mg/Kg/day). Leishmaniasis should be highly considered in the differential diagnosis of chronic ulcers in endemic
areas.
Keywords in Portuguese
Leishmaniose CutâneaUlcera do pé
Hiperplasia epitelial
Reação em Cadeia da Polimerase
Humanos
Keywords
Leishmaniasis, CutaneousFoot ulcer
Epithelial hyperplasia
Polymerase chain reaction
Humans
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