Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/20582
Title: Anti-CD4 treatment of NZB mice prevents the development of erythrocyte autoantibodies but hastens the appearance of anaemia.
Authors: Oiiveira, Geraldo Gileno de Sá
Hutchings, Patricia R
Lydyard, Peter M
Affilliation: University College London Medical School. Department o[" Immunology. London, UK
University College London Medical School. Department o[" Immunology. London, UK
University College London Medical School. Department o[" Immunology. London, UK
Abstract: New Zealand Black (NZB) mice spontaneousl2,. develop autoimmune haemolytic anaemia as the result of production of autoantibodies to erythrocytes. We have recently shown that antibodies to CD4 prevent the development of erythrocyte autoantibodies in young mice (Coombs' negative). In spite of this inhibition of erythrocyte autoantibody production, the anti-CD4-treated mice show a precocious and severe anaemia. Balb, c mice treated with the same protocol do not develop anaemia. Our results suggest that er.~- thropoiesis in NZB mice is particularly sensitive to depletion of CD4 + T cells.
Keywords: New Zealand black mouse
Anaemia
Antibody to CD4
Animals
keywords: Anemia hemolitica
Ratos
Antigeno CD4
Animais
Issue Date: 1994
Publisher: Elsevier
Citation: OLIVEIRA, G. G. S.; HUTCHINGS, P. R.; LYDYARD, P. M. Anti-CD4 treatment of NZB mice prevents the development of erythrocyte autoantibodies but hastens the appearance of anaemia. Immunology Letters, v. 39, p. 153-156, 1994.
Description: Oliveira, Geraldo Gileno de Sá “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
ISSN: 0165-2478
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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