Author | Santos, Hadassa Campos | |
Author | Horimoto, Andréa Roseli Vançan Russo | |
Author | Santos, Eduardo Martin Tarazona | |
Author | Soares, Fernanda Rodrigues | |
Author | Barreto, Mauricio Lima | |
Author | Horta, Bernardo Lessa | |
Author | Costa, Maria Fernanda Lima | |
Author | Gouveia, Mateus Henrique | |
Author | Machado, Moara | |
Author | Silva, Thiago M | |
Author | Sanches, José M | |
Author | Esteban, Nubia | |
Author | Magalhaes, Wagner Carlos Santos | |
Author | Rodrigues, Maíra Ribeiro | |
Author | Kehdy, Fernanda de Souza Gomes | |
Author | Pereira, Alexandre da Costa | |
Author | Brazilian EPIGEN Project Consortium. | |
Access date | 2017-08-03T16:50:49Z | |
Available date | 2017-08-03T16:50:49Z | |
Document date | 2016 | |
Citation | SANTOS, Hadassa Campos et al. A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set. Eur J Hum Genet, v. 24, n. 5, p. 725-31, 2016. | pt_BR |
ISSN | 1018-4813 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20508 | |
Language | eng | pt_BR |
Publisher | European Society of Human Genetics | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | genetica | pt_BR |
Title | A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/ejhg.2015.187 | |
Abstract | The Brazilian population is considered to be highly admixed. The main contributing ancestral populations were European and African, with Amerindians contributing to a lesser extent. The aims of this study were to provide a resource for determining and quantifying individual continental ancestry using the smallest number of SNPs possible, thus allowing for a cost- and time-efficient strategy for genomic ancestry determination. We identified and validated a minimum set of 192 ancestry informative markers (AIMs) for the genetic ancestry determination of Brazilian populations. These markers were selected on the basis of their distribution throughout the human genome, and their capacity of being genotyped on widely available commercial platforms. We analyzed genotyping data from 6487 individuals belonging to three Brazilian cohorts. Estimates of individual admixture using this 192 AIM panels were highly correlated with estimates using ~370 000 genome-wide SNPs: 91%, 92%, and 74% of, respectively, African, European, and Native American ancestry components. Besides that, 192 AIMs are well distributed among populations from these ancestral continents, allowing greater freedom in future studies with this panel regarding the choice of reference populations. We also observed that genetic ancestry inferred by AIMs provides similar association results to the one obtained using ancestry inferred by genomic data (370 K SNPs) in a simple regression model with rs1426654, related to skin pigmentation, genotypes as dependent variable. In conclusion, these markers can be used to identify and accurately quantify ancestry of Latin Americans or US Hispanics/Latino individuals, in particular in the context of fine-mapping strategies that require the quantification of continental ancestry in thousands of individuals. | pt_BR |
Affilliation | Universidade de São Paulo. Escola de Medicina. Laboratorio de Genetica e Cardiologia. São Paulo, S P, Brazil. | pt_BR |
Affilliation | Universidade de São Paulo. Escola de Medicina. Laboratorio de Genetica e Cardiologia. São Paulo, S P, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saude Publica. Salvador, BA, Brazil. | pt_BR |
Affilliation | Universidade Federal de Pelotas. Pelotas, RS, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saude Publica. Salvador, BA, Brazil. | pt_BR |
Affilliation | Universidade de São Paulo. Escola de Medicina. Laboratorio de Genetica e Cardiologia. São Paulo, S P, Brazil. | pt_BR |
Affilliation | Universidade de São Paulo. Escola de Medicina. Laboratorio de Genetica e Cardiologia. São Paulo, S P, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade de São Paulo. Escola de Medicina. Laboratorio de Genetica e Cardiologia. São Paulo, S P, Brazil. | pt_BR |
Subject | genetic | pt_BR |
Embargo date | 2028-01-01 | |