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2025-01-01
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TRANSMISSION-BLOCKING POTENTIAL OF MEFAS, A HYBRID COMPOUND DERIVED FROM ARTESUNATE AND MEFLOQUINE
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Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Malária Experimental e Humana. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Programa de Medicina Molecular. Faculdade de Medicina. Belo Horizonte, MG, Brazil/Malaria Discovery Performance Unit. GlaxoSmithKline R&D. Madrid, Spain
Malaria Discovery Performance Unit. GlaxoSmithKline R&D. Madrid, Spain
Malaria Discovery Performance Unit. GlaxoSmithKline R&D. Madrid, Spain
Malaria Discovery Performance Unit. GlaxoSmithKline R&D. Madrid, Spain
Fundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, Brazil
Fundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Malária Experimental e Humana. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Programa de Medicina Molecular. Faculdade de Medicina. Belo Horizonte, MG, Brazil
Malaria Discovery Performance Unit. GlaxoSmithKline R&D. Madrid, Spain
Malaria Discovery Performance Unit. GlaxoSmithKline R&D. Madrid, Spain
Malaria Discovery Performance Unit. GlaxoSmithKline R&D. Madrid, Spain
Fundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, Brazil
Fundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Malária Experimental e Humana. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Programa de Medicina Molecular. Faculdade de Medicina. Belo Horizonte, MG, Brazil
Abstract
Most antimalarial drugs target asexual parasites without reducing gametocyte formation or development. Drugs with dual roles, i.e., those that can target both asexual parasites and gametocytes, would improve the control of malaria. In the current study, MEFAS, a hybrid drug derived from mefloquine and artesunate that has been shown to be an active blood schizonticidal drug, was assessed to determine its ability to block the infectivity of Plasmodium falciparum gametocytes. MEFAS was 280 and 15 times more effective than mefloquine alone and artesunate alone, respectively.
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