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https://www.arca.fiocruz.br/handle/icict/20445
GENOMIC AND PHYLOGENETIC EVIDENCE OF VIPER RETROTRANSPOSON DOMESTICATION IN TRYPANOSOMATIDS
ADN Polimerasa Dirigida por ARN
Evolución Molecular
Affilliation
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Instituto de Biologia Molecular do Paraná, Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Instituto de Biologia Molecular do Paraná, Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Instituto de Biologia Molecular do Paraná, Curitiba, PR, Brasil.
Abstract
Transposable elements are important residents of eukaryotic genomes and eventually the host can domesticate them to serve cellular functions. We reported here a possible domestication event of the vestigial interposed retroelement (VIPER) in trypanosomatids. We found a large gene in a syntenic location in Leishmania braziliensis, L. panamensis, Leptomanas pyrrhocoris, and Crithidia fasciculata whose products share similarity in the C-terminal portion with the third protein of VIPER. No remnants of other VIPER regions surrounding the gene sequence were found. We hypothesise that the domestication event occurred more than 50 mya and the conservation of this gene suggests it might perform some function in the host species.
Keywords in Portuguese
TrypanosomatinaKeywords in Spanish
Elementos Transponibles de ADNADN Polimerasa Dirigida por ARN
Evolución Molecular
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