Author | Rocha, Paulo Novis | |
Author | Almeida, Roque Pacheco de | |
Author | Bacellar, Olívia | |
Author | Jesus, Amélia Maria Ribeiro de | |
Author | Correia Filho, Dalmo | |
Author | Cruz Filho, Álvaro | |
Author | Barral, Aldina Maria Prado | |
Author | Coffman, Robert L | |
Author | Carvalho Filho, Edgar Marcelino | |
Access date | 2017-07-19T14:17:55Z | |
Available date | 2017-07-19T14:17:55Z | |
Document date | 1999 | |
Citation | ROCHA, P. N. et al. Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis. The Journal of Infectious Diseases, v. 180, p. 1731–1734, 1999. | pt_BR |
ISSN | 0022-1899 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20147 | |
Description | Barral, Aldina Maria Prado “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | NIH (grant AI-30639), Financiadora de Estudos e Projetos, and Programa de Apoio aos Nu´cleos de Exceleˆncia. A.B. and E.M.C. are senior investigators of CNPq (Brazilian National Research Council). | pt_BR |
Language | eng | pt_BR |
Publisher | Oxfor University Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmania braziliensis | pt_BR |
Subject in Portuguese | Leishmaniose Cutânea | pt_BR |
Subject in Portuguese | Transtornos linfoproliferativos | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Subject in Portuguese | Citocinas | pt_BR |
Title | Down-Regulation of Th1 Type of Response in Early Human American Cutaneous Leishmaniasis | pt_BR |
Type | Article | pt_BR |
Abstract | This study examined the T cell responses in the early phase of Leishmania braziliensis
infection. Cytokine profiles, lymphoproliferative responses, and skin test results in 25 patients
with early cutaneous leishmaniasis (ECL; illness duration !60 days) were compared with those
in persons with late cutaneous leishmaniasis (LCL; illness duration 12 months). Absent or
low lymphoproliferative responses were observed in 8 (32%) of 25 patients and an absence of
interferon (IFN)–g production in 9 (41%) of 22 patients prior to therapy. IFN-g production
in ECL (mean 5 SD) was lower than in LCL (2935346 vs. 7475377 pg/mL, respectively;
P ! .01). In contrast, interleukin (IL)–10 production in ECL (mean 5 SD) was higher than
in LCL (246556 vs. 50541 pg/mL, respectively;P ! .01) .Restoration of lymphoproliferative
responses and IFN-g production was achieved when monoclonal antibody to IL-10 or IL-12
was added to the cultures. These results show that T cell responses during early-phase infection
are down-regulated by IL-10 and may facilitate parasite multiplication. | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de Uberaba. Uberaba, MG, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | DNAX Research Institute. Palo Alto, California | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Subject | Leishmania braziliensis | pt_BR |
Subject | Leishmaniasis, Cutaneous | pt_BR |
Subject | Lymphoproliferative disorders | pt_BR |
Subject | Humans | pt_BR |
Subject | Cytokine | pt_BR |