Author | Iani, Felipe Campos de Melo | |
Author | Caldas, Sérgio | |
Author | Duarte, Myrian Morato | |
Author | Cury, Ana Luisa Furtado | |
Author | Cecílio, Alzira Batista | |
Author | Costa, Pedro Augusto Carvalho | |
Author | Antonelli, Lis Ribeiro do Valle | |
Author | Gollob, Kenneth J. | |
Access date | 2017-07-17T17:46:43Z | |
Available date | 2017-07-17T17:46:43Z | |
Document date | 2016 | |
Citation | IANI, Felipe Campos de Melo et al. Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8. Am J Trop Med Hyg., v. 95, n. 1, p. 193–200, 2016. | pt_BR |
ISSN | 0002-9637 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20111 | |
Language | eng | pt_BR |
Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Dengue | pt_BR |
Title | Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8. | pt_BR |
Type | Article | pt_BR |
DOI | 10.4269/ajtmh.15-0537 | |
Abstract | Dengue is responsible for a wide range of clinical manifestations, ranging from asymptomatic infections to severe cases. The alteration of cytokine levels correlated with clinical characteristics can help determine prognostic markers of the disease and the identification of targets for immunotherapy. We measured the viral load, serotype, and cytokine levels of 212 serum samples from patients with acute dengue infection during days 1–4 after the onset of symptoms. The patients were classified as either with hemorrhagic manifestations (HM) or with no hemorrhagic manifestations (NHM). The cytokines interleukin-6 (IL-6), IL-8, and IL-10 were increased (P < 0.05) in the dengue virus+ group, compared with the control group. A higher viral load (P < 0.05) and IL-6 was detected in the HM group compared with the NHM group. Interestingly, the NHM group demonstrated a significant positive correlation between inflammatory (IL-6 and 8) and anti-inflammatory (IL-10) cytokines, whereas the HM group did not. These findings suggest that a disturbance in the balance of inflammatory cytokines IL-6 and IL-8 with the anti-inflammatory cytokine, IL-10, combined with the high levels of IL-6 and viral load, characterize possible mechanisms related to the formation of HM. | pt_BR |
Affilliation | Fundação Ezequiel Dias. Instituto Octávio Magalhães. Divisão de Epidemiologia e Controle de Doenças. Belo Horizonte, MG, Brazil/Hospital Santa Casa. Instituto de Ensino e Pesquisa. Programa de Pós-graduação em Medicina e Biomedicina. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Ezequiel Dias. Diretoria de Pesquisa e Desenvolvimento. Divisão de Plataformas Tecnológicas. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Ezequiel Dias. Instituto Octávio Magalhães. Divisão de Epidemiologia e Controle de Doenças. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Ezequiel Dias. Instituto Octávio Magalhães. Divisão de Epidemiologia e Controle de Doenças. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Ezequiel Dias. Diretoria de Pesquisa e Desenvolvimento. Divisão de Plataformas Tecnológicas. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Hospital Santa Casa. Instituto de Ensino e Pesquisa. Programa de Pós-graduação em Medicina e Biomedicina. Belo Horizonte, MG, Brazil/Institutos Nacionais de Ciências e Tecnologia-Doenças Tropicais. Belo Horizonte, MG, Brazil | pt_BR |
Subject | Dengue | pt_BR |
Embargo date | 2020-01-01 | |