Author | Fernandes, Juliana Dumet | |
Author | Hsieh, Ricardo | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Author | Brandao, Miguel Angelo Rodrigues | |
Author | Lourenço, Silvia Vanessa | |
Author | Sangueza, Martin | |
Author | Nico, Marcello Menta Simonsen | |
Access date | 2017-07-12T16:51:53Z | |
Available date | 2017-07-12T16:51:53Z | |
Document date | 2015 | |
Citation | FERNANDES, J. D. et al. MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma. American Journal of Dermatopathology, v. 37, n. 12, p. 892–897, 2015. | pt_BR |
ISSN | 0193-1091 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20055 | |
Description | Freitas, Luiz Antônio Rodrigues de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Language | eng | pt_BR |
Publisher | Lippincott, Williams & Wilkins | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Melanoma | pt_BR |
Subject in Portuguese | Acral | pt_BR |
Subject in Portuguese | Câncer de pele | pt_BR |
Subject in Portuguese | MAPK quinases | pt_BR |
Title | MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma | pt_BR |
Type | Article | pt_BR |
DOI | 10.1097/DAD.0000000000000317 | |
Abstract | The etiology and pathogenesis of lentiginous acral melanomas are poorly understood. Recent studies have postulated that DNA repair mechanisms and cell growth pathways are involved in the development of melanoma, particularly changes in the MAPK pathways (RAS, BRAF, MEK 1/2, and ERK 1/2). The aim of this study is to assess the status of the MAP kinase pathways in the pathogenesis of acral melanomas. The authors examined the components of the RAS-RAF-MEK-ERK cascades by immunohistochemistry in a series of 16 primary acral melanomas by tissue microarray. The expression of MAP kinase cascade proteins changed in most cases. The authors observed that 57.14% of cases were BRAF positive and that 61.53%, 71.42%, and 71.42% of cases were positive for MEK2, ERK1, and ERK2, respectively; RAS was not expressed in 92.31%, and all cases were negative for MEK1. The absence of RAS and positivity for MEK2, ERK1, and ERK2 were most seen in invasive cases with high thickness. These aspects of the MAPK pathway require further examination in acral melanomas between different populations. Nevertheless, the results highlight significant alterations in the MAP kinase cascades that are related to histological indicators of prognosis in primary acral melanomas. | pt_BR |
Affilliation | Federal University of Bahia. Medical School. Department of Dermatology. Salvador, BA, Brazil | pt_BR |
Affilliation | University of São Paulo. Dental School. Department of General Pathology. São Paulo, SP, Brazil | pt_BR |
Affilliation | Federal University of Bahia. Medical School. Department of Pathology. Salvador, BA, Brazil | pt_BR |
Affilliation | AMO. Oncological Clinic Care. Salvador, BA, Brazil | pt_BR |
Affilliation | University of São Paulo. Dental School. Department of General Pathology. São Paulo, SP, Brazil / University of São Paulo. Medical School. Department of Dermatology. São Paulo, SP, Brazil | pt_BR |
Affilliation | Hospital Obrero. Department of Surgical Pathology. La Paz, Bolivia | pt_BR |
Affilliation | University of São Paulo. Medical School. Department of Dermatology. São Paulo, SP, Brazil | pt_BR |
Subject | Melanoma | pt_BR |
Subject | Acral | pt_BR |
Subject | Skin cancer | pt_BR |
Subject | MAPK kinase | pt_BR |