Author | Cardillo, Fabíola | |
Author | Pinho, Rosa Teixeira de | |
Author | Antas, Paulo Renato Zuquim | |
Author | Mengele Junior, José Orivaldo | |
Access date | 2017-07-06T12:55:35Z | |
Available date | 2017-07-06T12:55:35Z | |
Document date | 2015 | |
Citation | CARDILLO, F. et al. Immunity and immune modulation in Trypanosoma cruzi infection. FEMS Pathogens and Disease, v. 73, 2015. | pt_BR |
ISSN | 2049-632X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/19739 | |
Sponsorship | CNPq, PAPES/FIOCRUZ and FOGFMP/FASE. PRZA is granted with CNPq and FAPERJ | pt_BR |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Célula T de memória | pt_BR |
Subject in Portuguese | Célula T reguladora | pt_BR |
Subject in Portuguese | Célula T gama delta | pt_BR |
Subject in Portuguese | Interleucina-17 | pt_BR |
Subject in Portuguese | Célula supressora derivada de mieloides | pt_BR |
Title | Immunity and immune modulation in Trypanosoma cruzi infection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/femspd/ftv082 | |
Abstract | Chagas disease is caused by the protozoan Trypanosoma cruzi. The parasite reaches the secondary lymphoid organs, the heart, skeletal muscles, neurons in the intestine and esophagus among other tissues. The disease is characterized by mega syndromes, which may affect the esophagus, the colon and the heart, in about 30% of infected people. The clinical manifestations associated with T. cruzi infection during the chronic phase of the disease are dependent on complex interactions between the parasite and the host tissues, particularly the lymphoid system that may either result in a balanced relationship with no disease or in an unbalanced relationship that follows an inflammatory response to parasite antigens and associated tissues in some of the host organs and/or by an autoimmune response to host antigens. This review discusses the findings that support the notion of an integrated immune response, considering the innate and adaptive arms of the immune system in the control of parasite numbers and also the mechanisms proposed to regulate the immune response in order to tolerate the remaining parasite load, during the chronic phase of infection. This knowledge is fundamental to the understanding of the disease progression and is essential for the development of novel therapies and vaccine strategies. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Faculty of Medicine of Petropolis. Petrópolis, RJ, Brazil | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Memory T cell | pt_BR |
Subject | Regulatory T cell | pt_BR |
Subject | Gamma delta T cell | pt_BR |
Subject | Interleukin-17 | pt_BR |
Subject | Myeloid-derived suppressor cell | pt_BR |