Author | Schaut, Robert G. | |
Author | Lamb, Ian M. | |
Author | Toepp, Angela J. | |
Author | Scott, Benjamin | |
Author | Aguiar, Carolina de Oliveira Mendes | |
Author | Coutinho, Jose F. V. | |
Author | Jeronimo, Selma M. B. | |
Author | Wilson, Mary E. | |
Author | Harty, John T. | |
Author | Waldschmidt, Thomas J. | |
Author | Petersen, Christine A. | |
Access date | 2017-06-23T19:37:20Z | |
Available date | 2017-06-23T19:37:20Z | |
Document date | 2016 | |
Citation | SCHAUT, Robert G. et al. Regulatory IgDhi B Cells Suppress T cell Function via IL-10 and PD-L1 During Progressive Visceral Leishmaniasis. J. Immunol., v.196, n.10, p.4100-4109, May 2016. | pt_BR |
ISSN | 0022-1767 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/19506 | |
Language | eng | pt_BR |
Publisher | The American Association of Immunologists | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Leishmaniose visceral | pt_BR |
Subject in Portuguese | Células reguladoras IgDhi B | pt_BR |
Subject in Portuguese | Interleucina-10 | pt_BR |
Title | Regulatory IgDhi B Cells Suppress T Cell Function via IL-10 and PD-L1 during Progressive Visceral Leishmaniasis | pt_BR |
Type | Article | pt_BR |
DOI | 10.4049/jimmunol.1502678 | |
Abstract | During visceral leishmaniasis (VL), Th1-based inflammation is induced to control intracellular parasites. Inflammation-based pathology was shown to be dampened by IL-10 and eventual programmed death 1-mediated T cell exhaustion. Cell type(s) responsible for the initiation of T cell-produced IL-10 during VL are unknown. CD19(+), CD5(-), CD1d(-), IgD(hi) regulatory B cells from healthy controls produced IL-10 in the absence of infection or stimulation, in contrast to IgD(lo/neg) B cells. IgD(hi) B cells may have a de novo versus induced regulatory program. The population of IgD(hi) B cells increased 3-fold as VL progressed. B cells from VL dogs were necessary and sufficient to suppress Th1 cell effector function. IgD(hi) B cells induced IL-10 production by T cells and IgD(lo) B cells. Blockage of B cell-specific PD-L1 restored Th1 responses. IgD(hi) regulatory B cells represent a novel regulatory B cell that may precipitate T cell exhaustion during VL. | pt_BR |
Affilliation | University of Iowa College of Public Health. Department of Epidemiology. Iowa City, Iowa, USA. | pt_BR |
Affilliation | University of Iowa College of Public Health. Department of Epidemiology. Iowa City, Iowa, USA. | pt_BR |
Affilliation | University of Iowa College of Public Health. Department of Epidemiology. Iowa City, Iowa, USA. | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Norte. Instituto de Medicina Tropical. Departamento de Bioquímica. Programa de Pós-Graduação em Saúde. Natal, RN, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Norte. Instituto de Medicina Tropical. Departamento de Bioquímica. Programa de Pós-Graduação em Saúde. Natal, RN, Brasil / Secretaria de Estado de Saúde. Centro de Zoonoses. Natal, RN, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio Grande do Norte. Instituto de Medicina Tropical. Departamento de Bioquímica. Programa de Pós-Graduação em Saúde. Natal, RN, Brasil. | pt_BR |
Affilliation | University of Iowa Carver College of Medicine. Immunology Program. Iowa City, Iowa, USA. | pt_BR |
Affilliation | University of Iowa Carver College of Medicine. Immunology Program. Iowa City, Iowa, USA. | pt_BR |
Affilliation | University of Iowa Carver College of Medicine. Immunology Program. Iowa City, Iowa, USA. | pt_BR |
Affilliation | University of Iowa College of Public Health. Department of Epidemiology. Iowa City, Iowa, USA. | pt_BR |
Subject | Visceral Leishmaniasis | pt_BR |
Subject | Regulatory IgDhi B Cells | pt_BR |
Subject | IL-10 | pt_BR |
e-ISSN | 1550-6606 | |
Embargo date | 2030-01-01 | |