Author | Fertrin, Kleber Yotsumoto | |
Author | Gonçalves, Marilda de Souza | |
Author | Saad, Sara Teresinha Olalla | |
Author | Costa, Fernando Ferreira | |
Access date | 2017-06-09T17:18:52Z | |
Available date | 2017-06-09T17:18:52Z | |
Document date | 2002 | |
Citation | FERTRIN, K. Y. et al. Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil. American Journal of Medical Genetics Part A, v. 108, p. 117-119, 2002. | pt_BR |
ISSN | 1552-4825 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/19359 | |
Description | Marilda de Souza Gonçalves “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
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FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo) e CNPq (Conselho Nacional de Desenvolvimento Científico e Pesquisa) | pt_BR |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Glucuronosiltransferase | pt_BR |
Subject in Portuguese | Polimorfismo (genética) | pt_BR |
Subject in Portuguese | Regiões promotoras, genética | pt_BR |
Subject in Portuguese | Grupos etnicos | pt_BR |
Subject in Portuguese | Alelos | pt_BR |
Subject in Portuguese | Brazil | pt_BR |
Title | Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil | pt_BR |
Type | Article | pt_BR |
Abstract | A polymorphism in the promoter region of the UDP-glucuronosyltransferase 1 (UGT1A) gene is associated with Gilbert syndrome (GS), a benign form of mild unconjugated hyperbilirubinemia. We genotyped 157 individuals from Brazil, comprising 71 Caucasians, 54 African-derived subjects, and 32 Parakanã Indians. Frequencies of the alelle (TA)(7) associated with GS found in this study were 0.324, 0.407, and 0.328, respectively. The genotype frequencies differed significantly between Caucasians and African-derived individuals. The high frequencies of (TA)(7) polymorphism among the three groups confirm previous data that this polymorphism is very ancient and appears to be distributed throughout the world. | pt_BR |
Affilliation | Unicamp. Hemocentro. Cidade Universitária Zeferino Vaz. Campinas, SP, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Unicamp. Hemocentro. Cidade Universitária Zeferino Vaz. Campinas, SP, Brasil | pt_BR |
Affilliation | Unicamp. Hemocentro. Cidade Universitária Zeferino Vaz. Campinas, SP, Brasil | pt_BR |
Subject | Gilbert syndrome | pt_BR |
Subject | UGT1A | pt_BR |
Subject | TA polymorphism | pt_BR |
Subject | Amerindians | pt_BR |
Subject | Parakanã indians | pt_BR |
DeCS | Glucuronosiltransferase | pt_BR |
DeCS | Polimorfismo (genética) | pt_BR |
DeCS | Regiões promotoras, genética | pt_BR |
DeCS | Grupos etnicos | pt_BR |
DeCS | Alelos | pt_BR |
DeCS | Brazil | pt_BR |