Author | Arruda, Valder Roberval | |
Author | Siqueira, Lucia Helena de | |
Author | Gonçalves, Marilda de Souza | |
Author | von Zuben, Paula M | |
Author | Soares, Manoel C.P | |
Author | Menezes, Raimundo | |
Author | Bizzacchi, Joyce Maria Annichino | |
Author | Costa, Fernando F | |
Access date | 2017-06-07T19:03:13Z | |
Available date | 2017-06-07T19:03:13Z | |
Document date | 1998 | |
Citation | ARRUDA, V. R. et al. Prevalence of the Mutation C677 ® T in the Methylene Tetrahydrofolate Reductase Gene Among Distinct Ethnic Groups in Brazil. American Journal of Medical Genetics, v. 78, p. 332–335, 1998. | pt_BR |
ISSN | 1552-4825 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/19343 | |
Description | Marilda de Souza Gonçalves “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Metilenetetra-hidrofolato redutase | pt_BR |
Subject in Portuguese | Homocisteína | pt_BR |
Subject in Portuguese | Ácido fólico | pt_BR |
Subject in Portuguese | Doença arterial | pt_BR |
Subject in Portuguese | Trombose venosa | pt_BR |
Title | Prevalence of the Mutation C677 ® T in the Methylene Tetrahydrofolate Reductase Gene Among Distinct Ethnic Groups in Brazil | pt_BR |
Type | Article | pt_BR |
Abstract | Vascular disease is a serious public health
problem in the industrialized world, and is a
frequent cause of death among the adult
population of Brazil. Mild hyperhomocysteinemia
has been identified as a risk factor
for arterial disease, venous thrombosis, and
neural tube defects. Individuals homozygous
for the thermolabile variant of methylenetetrahydrofolate
reductase (MTHFR-T)
are found in 5–15% of the general population
and have significantly elevated plasma homocysteine
levels which represent one of
the genetic risk factors for vascular diseases.
We have analyzed the prevalence of
individuals homozygous for the MTHFR-T
in 327 subjects representing the three distinct
ethnic groups in Brazil. The prevalence
of homozygotes for the mutated allele
MTHFR-T was high among persons of Caucasian
descent (10%) and considerably
lower among Black (1.45%) and Indians persons
populations (1.2%). These data suggest
that screening for the MTHFR-T allele
should help in identifying individuals with
a high risk of vascular disease among populations
with a heterogeneous background | pt_BR |
Affilliation | State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil | pt_BR |
Affilliation | State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Salvador, BA, Brazil | pt_BR |
Affilliation | State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil | pt_BR |
Affilliation | Evandro Chagas Institute. Belém, PA, Brazil | pt_BR |
Affilliation | Evandro Chagas Institute. Belém, PA, Brazil | pt_BR |
Affilliation | State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil | pt_BR |
Affilliation | State Universtty of Campinas. Hematology Hernotherapy Center. Department of Clinical Medicine. Campinas, SP, Brasil | pt_BR |
Subject | Methylenetetrahydrofolate reductase gene | pt_BR |
Subject | Homocysteine | pt_BR |
Subject | Folic acid | pt_BR |
Subject | Arterial disease | pt_BR |
Subject | Venous thrombosis | pt_BR |
DeCS | Metilenetetra-hidrofolato redutase | pt_BR |
DeCS | Homocisteína | pt_BR |
DeCS | Ácido fólico | pt_BR |
DeCS | Doença arterial | pt_BR |
DeCS | Trombose venosa | pt_BR |