Author | Teva, A. | |
Author | Porrozzi, R. | |
Author | Oliveira Neto, M. P. | |
Author | Grimaldi Jr., Gabriel | |
Access date | 2017-06-06T15:51:45Z | |
Available date | 2017-06-06T15:51:45Z | |
Document date | 2005 | |
Citation | TEVA, A. et al. Responses of Leishmania (Viannia) braziliensis Cutaneous Infection to N-Methylglucamine Antimoniate in the Rhesus Monkey (Macaca mulatta) Model. J. Parasitol., v.91, n,4, p.976–978, Aug. 2005. | pt_BR |
ISSN | 0022-3395 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/19324 | |
Language | eng | pt_BR |
Publisher | American Society of Parasitologists | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Macaca mulatta | pt_BR |
Subject in Portuguese | Leishmania cutânea | pt_BR |
Subject in Portuguese | Infecção cutânea | pt_BR |
Subject in Portuguese | Antimônio | pt_BR |
Title | Responses of Leishmania (Viannia) braziliensis cutaneous infection to N-methylglucamine antimoniate in the rhesus monkey (Macaca mulatta) model | pt_BR |
Type | Article | pt_BR |
DOI | 10.1645/GE-3486RN.1 | |
Abstract | The antileishmanial efficacy of the reference drug N-methylglucamine antimoniate (Glucantime) was evaluated in groups of rhesus monkeys with acute and chronic Leishmania (Viannia) braziliensis cutaneous infection. The therapeutic responses in experimental animals to either a low dose (5 mg/kg body wt/day for 28 days) or a routine dose (20 mg/kg/day for 28 days) of pentavalent antimony were similar to those reported in the human disease. Primates were cured of their lesions after treatment, but with cryptic parasitism and/or relapse. The rhesus model of L. (V.) braziliensis cutaneous leishmaniasis therefore provides an additional resource for preclinical trials with newer drugs. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | Rhesus Monkey | pt_BR |
Subject | Leishmania (Viannia) braziliensis | pt_BR |
Subject | Cutaneous Infection | pt_BR |
Subject | N-Methylglucamine Glucantime | pt_BR |
e-ISSN | 1937-2345 | |
Embargo date | 2030-01-01 | |