Author | Lachtermacher, Stephan | |
Author | Esporcatte, Bruno .L B. | |
Author | Fortes, Fábio da Silva de Azevedo | |
Author | Rocha, Nazareth Novaes | |
Author | Montalvão, Fabrício | |
Author | Costa, Patricia C. | |
Author | Belem, Luciano | |
Author | Rabischoffisky, Arnaldo | |
Author | Faria Neto, Hugo C. C. | |
Author | Vasconcellos, Rita | |
Author | Iacobas, Dumitru A. | |
Author | Iacobas, Sanda | |
Author | Spray, David C. | |
Author | Thomas, Neil M. | |
Author | Goldenberg, Regina C. S. | |
Author | Carvalho, Antonio C. Campos de | |
Access date | 2017-05-30T16:21:36Z | |
Available date | 2017-05-30T16:21:36Z | |
Document date | 2012 | |
Citation | LACHTERMACHER, Stephan; et al. Functional and Transcriptomic Recovery of Infarcted Mouse Myocardium Treated with Bone Marrow Mononuclear Cells. Stem Cell Rev., v.8, n.1, p.251-261, Mar. 2012. | pt_BR |
ISSN | 1550-8943 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/19068 | |
Language | spa | pt_BR |
Publisher | Humana Press | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Função cardíaca | pt_BR |
Subject in Portuguese | Insuficiência cardíaca | pt_BR |
Subject in Portuguese | Análise de microarranjos | pt_BR |
Subject in Portuguese | Resposta imunolinflamatória | pt_BR |
Title | Functional and transcriptomic recovery of infarcted mouse myocardium treated with bone marrow mononuclear cells | pt_BR |
Type | Article | pt_BR |
DOI | 10.1007/s12015-011-9282-2 | |
Abstract | Although bone marrow-derived mononuclear cells (BMNC) have been extensively used in cell therapy for cardiac diseases, little mechanistic information is available to support reports of their efficacy. To address this shortcoming, we compared structural and functional recovery and associated global gene expression profiles in post-ischaemic myocardium treated with BMNC transplantation. BMNC suspensions were injected into cardiac scar tissue 10 days after experimental myocardial infarction. Six weeks later, mice undergoing BMNC therapy were found to have normalized antibody repertoire and improved cardiac performance measured by ECG, treadmill exercise time and echocardiography. After functional testing, gene expression profiles in cardiac tissue were evaluated using high-density oligonucleotide arrays. Expression of more than 18% of the 11981 quantified unigenes was significantly altered in the infarcted hearts. BMNC therapy restored expression of 2099 (96.2%) of the genes that were altered by infarction but led to altered expression of 286 other genes, considered to be a side effect of the treatment. Transcriptional therapeutic efficacy, a metric calculated using a formula that incorporates both recovery and side effect of treatment, was 73%. In conclusion, our results confirm a beneficial role for bone marrow-derived cell therapy and provide new information on molecular mechanisms operating after BMNC transplantation on post ischemic heart failure in mice. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Departamento de Fisiologia e Farmacologia. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Pró-Cardíaco. PROCEP-Centro de Ensino e Pesquisa. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Hospital Pró-Cardíaco. PROCEP-Centro de Ensino e Pesquisa. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Imunobiologia. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Albert Einstein College of Medicine. Bronx, USA. | pt_BR |
Affilliation | Albert Einstein College of Medicine. Bronx, USA. | pt_BR |
Affilliation | Albert Einstein College of Medicine. Bronx, USA. | pt_BR |
Affilliation | Albert Einstein College of Medicine. Bronx, USA. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Heart failure | pt_BR |
Subject | Microarray analysis | pt_BR |
Subject | Immune-inflammatory response | pt_BR |
Subject | Cardiac function | pt_BR |
e-ISSN | 1558-6804 | |
Embargo date | 2030-01-01 | |