Author | Lima, Luciane Mota | |
Author | Santos, Silvane Braga | |
Author | Oliveira, Ricardo Riccio | |
Author | Cardoso, Luciana Santos | |
Author | Oliveira, Sérgio Costa | |
Author | Góes, Alfredo Miranda | |
Author | Loukas, Alex | |
Author | Carvalho Filho, Edgar Marcelino | |
Author | Araújo, Maria Ilma | |
Access date | 2017-05-26T16:36:52Z | |
Available date | 2017-05-26T16:36:52Z | |
Document date | 2013 | |
Citation | LIMA, L. M. et al. Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1. Neuroimmunomodulation, v. 20, p. 233–238, 2013. | pt_BR |
ISSN | 1021-7401 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/19018 | |
Description | Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | CNPQ (Universal 479417/2008 3) and NIH (R01AI079238A). | pt_BR |
Language | eng | pt_BR |
Publisher | Karger Publishers | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Vírus linfotrópico de células T humanas tipo 1 | pt_BR |
Subject in Portuguese | Schistosoma spp. Antígenos | pt_BR |
Subject in Portuguese | Interferon-y | pt_BR |
Subject in Portuguese | Interleucina-10 | pt_BR |
Subject in Portuguese | Antígenos | pt_BR |
Title | Schistosoma antigens downmodulate the in vitro inflammatory response in individuals infected with human T cell lymphotropic virus type 1 | pt_BR |
Type | Article | pt_BR |
DOI | 10.1159/000348700 | |
Abstract | Human T cell lymphotropic virus type 1 (HTLV-1) is the causal agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). While the immune response to HTLV-1 infection is polarized to the Th1-type, chronic helminth infections drive the Th2- and T regulatory-type, and are able to downregulate the inflammatory response in some autoimmune diseases. Objective: To evaluate whether
Schistosoma spp. antigens alter the in vitro cytokine
response in HTLV-1 infection. Methods: The recombinant
Schistosoma antigens Sm29 and ShTSP2 (tetraspanin) and
PIII, a fraction of the Schistosoma mansoni adult worm antigen
were added to peripheral blood mononuclear cell
(PBMC) cultures of HTLV-1-infected individuals and the levels
of interferon (IFN)-γ and interleukin (IL)-10 in the supernatants
were measured using the ELISA sandwich technique.
Results: Compared to the levels of cytokine in nonstimulated
cultures, the levels of IFN-γ were reduced in 50, 47 and 50% of patients by the presence of Sm29, ShTsp2 and PIII,
respectively. The downregulation of IFN-γ production in the
presence of Sm29 antigen was observed mainly in subjects
who had lower basal levels of this cytokine. The levels of
IL-10, however, increased by the addition of the three antigens
in the cultures in 74, 62 and 44% of individuals, respectively.
In addition, there was a decrease in the ratio of IFN-γ/
IL-10 levels in cultures stimulated with Sm29 and ShTSP2
when compared to nonstimulated ones. Conclusions: The
Schistosoma spp. antigens used in this study were able to
downmodulate IFN-γ production in vitro in HTLV-1 infection.
This may be associated with the increased levels of IL-10 induced
by the antigens. | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Ciências da Vida. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de BioquÍmica e Imunologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de BioquÍmica e Imunologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Queensland Institute of Medical Research. Division of Infectious Diseases. Brisbane, Qld, Australia | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brasil | pt_BR |
Subject | Human T cell lymphotropic virus type 1 | pt_BR |
Subject | Schistosoma spp | pt_BR |
Subject | Interferon-γ | pt_BR |
Subject | Interleukin-10 | pt_BR |
Subject | Antigens | pt_BR |
DeCS | Vírus linfotrópico de células T humanas tipo 1 | pt_BR |
DeCS | Schistosoma | pt_BR |
DeCS | Interferon | pt_BR |
DeCS | Interleucina-10 | pt_BR |
DeCS | Antígenos | pt_BR |