Author | Marin, Michel Abanto | |
Author | Fonseca, Erica | |
Author | Encinas, Fernando | |
Author | Freitas, Fernanda | |
Author | Camargo, Dhian Almeida | |
Author | Coimbra, Roney Santos | |
Author | Filippis, Ivano de | |
Author | Vicente, Ana Carolina | |
Access date | 2017-05-25T18:53:38Z | |
Available date | 2017-05-25T18:53:38Z | |
Document date | 2017 | |
Citation | MARIN, Michel Abanto et. al. The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire. Scientific Reports, v. 7, n. 1, p. 1-11, 2007. | pt_BR |
ISSN | 2045-2322 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/19015 | |
Language | eng | pt_BR |
Publisher | Nature | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Neisseria meningitidis | pt_BR |
Subject in Portuguese | Nucleotídeos | pt_BR |
Subject in Portuguese | Genética Microbiana | pt_BR |
Subject in Portuguese | Patógenos | pt_BR |
Title | The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/s41598-017-01671-x | |
Abstract | Neisseria meningitidis infections are a major issue for global health. The invasive MenC ST-103 clonal complex (CC103) has been the most prevalent in meningococcal outbreaks in Brazil, occurring also in several countries worldwide. Here we have analysed the population structure and accessory genome of MenC CC103 strains from a global perspective. An in-depth phylogenomic analysis revealed a lineage of N. meningitidis causing meningitis in Brazil and the United Kingdom. This lineage was also characterized as harbouring a particular accessory genome composed of CRISPR/Cas and restriction modification systems. This lineage was also characterized by a genomic island resembling an integrative and conjugative element. This island carried genes potentially associated with virulence and fitness. We propose this accessory gene repertoire could be contributing to the spatial-temporal persistence of the invasive MenC CC103 lineage. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Ezequiel Dias. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Neisseria meningitidis | pt_BR |
Subject | Genome Informatics | pt_BR |
Subject | High-throughput Screening | pt_BR |
Subject | Infectious-disease diagnostics | pt_BR |
Subject | Microbial genetics | pt_BR |
Subject | Pathogens | pt_BR |
DeCS | Neisseria meningitidis | pt_BR |
DeCS | Genoma Bacteriano | pt_BR |
DeCS | Sequenciamento de Nucleotídeos em Larga Escala | pt_BR |
DeCS | Genética Microbiana | pt_BR |
DeCS | Noxas | pt_BR |