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https://www.arca.fiocruz.br/handle/icict/1895
EFFECTS OF UMBELLIFERONE IN A MURINE MODEL OF ALLERGIC AIRWAY INFLAMMATION
Pneumonia
Umbeliferonas
Antiasmáticos
Modelos Animais de Doenças
Camundongos Endogâmicos BALB C
Author
Affilliation
Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil
Instituto de Ciências Biomédicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, PB, Brasil
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, PB, Brasil
Colegiado do Curso de Medicina, Universidade Federal do Vale do São Francisco, Petrolina, PE, Brasil
Departamento de Ciências Biológicas, Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brasil
Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil
Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil
Instituto de Ciências Biomédicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, PB, Brasil
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, PB, Brasil
Colegiado do Curso de Medicina, Universidade Federal do Vale do São Francisco, Petrolina, PE, Brasil
Departamento de Ciências Biológicas, Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brasil
Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil
Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil
Abstract
The therapeutic effects of umbelliferone (30, 60 and 90 mg/kg), a coumarin isolated from Typha domingensis (Typhaceae) were investigated in a mouse model of bronchial asthma. BALB/c mice were immunized and challenged by nasal administration of ovalbumin. Treatment with umbelliferone (60 and 90 mg/kg) caused a marked reduction of cellularity and eosinophil numbers in bronchoalveolar lavage fluids from asthmatic mice. In addition, a decrease in mucus production and lung inflammation were observed in mice treated with umbelliferone. A reduction of IL-4, IL-5, and IL-13, but not of IFN-gamma, was found in bronchoalveolar lavage fluids of mice treated with umbelliferone, similar to that observed with dexamethasone. The levels of ovalbumin-specific IgE were not significantly altered after treatment with umbelliferone. In conclusion, our results demonstrate that umbelliferone attenuates the alteration characteristics of allergic airway inflammation. The investigation of the mechanisms of action of this molecule may contribute for the development of new drugs for the treatment of asthma.
DeCS
AsmaPneumonia
Umbeliferonas
Antiasmáticos
Modelos Animais de Doenças
Camundongos Endogâmicos BALB C
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