Author | Clarêncio, Jorge | |
Author | Oliveira, Camila Indiani de | |
Author | Favali, Cecilia Beatriz Fiuza | |
Author | Medina, Omar | |
Author | Caldas, Arlene de Jesus Mendes | |
Author | Costa, Carlos Henrique Nery | |
Author | Costa, Dorcas Lamounier | |
Author | Brodskyn, Claudia Ida | |
Author | Barral, Aldina Maria Prado | |
Author | Barral Netto, Manoel | |
Access date | 2011-04-12T21:55:34Z | |
Available date | 2011-04-12T21:55:34Z | |
Document date | 2008 | |
Citation | CLARÊNCIO, J. et al. Could the lower frequency of CD8+CD18+CD45RO+ lymphocytes be biomarkers of human VL? International Immunolgy, v.21, n.2, p. 137-144, 2008. | pt_BR |
ISSN | 0953-8178 | |
URI | https://www.arca.fiocruz.br/handle/icict/1890 | |
Language | eng | pt_BR |
Rights | open access | |
Title | Could the lower frequency of CD8+CD18+CD45RO+ lymphocytes be biomarkers of human VL? | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/intimm/dxn131 | |
Abstract | Toward obtaining a more comprehensive understanding of factors governing activation and/or
function during visceral leishmaniasis (VL), we have compared active disease (pre-treatment) versus
post-chemotherapy immune response in VL patients by means of ex vivo staining with different cell
markers. Our results show that during active disease, the frequency of T cells positive for CD25,
CTLA-4 and CD45RO was significantly lower in VL patients compared with healthy controls, whereas
cells staining positive for Annexin V and CD95 were significantly higher. In all cases, chemotherapy
was able to restore these frequencies to normal levels. Interestingly, significant differences in the
frequency of CD18 and in the frequency of CD45RO-positive cells were observed in the CD81 T cell
subset. These two frequencies were also significantly higher in bone marrow when compared with
peripheral blood, suggesting a possible compartmentalization of certain CD81 T cell populations
during active disease. Given that CD81 T cells have been shown to play an essential role in immunity
to infection with Leishmania, our data indicate that the lower frequency of CD181 and CD45RO1
lymphocytes in the bone marrow CD81 T cell subset may be considered a biomarker of acute VL. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal do Maranhão. São Luis, MA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | CD 18 | pt_BR |
Subject | Flow cytometry | pt_BR |
Subject | Leishmania | pt_BR |
DeCS | Antígenos CD18 | pt_BR |
DeCS | Antígenos CD45 | pt_BR |
DeCS | Antígenos de Protozoários | pt_BR |
DeCS | Linfócitos T CD8-Positivos | pt_BR |
DeCS | Leishmania infantum | pt_BR |
DeCS | Leishmaniose visceral | pt_BR |
DeCS | Sub-Populações de Linfócitos T | pt_BR |
DeCS | Citometria de Fluxo | pt_BR |