Author | Martel, Nora | |
Author | Cotte, Laurent | |
Author | Trabaud, Mary-Anne | |
Author | Trepo, Christian | |
Author | Zoulim, Fabien | |
Author | Gomes, Selma A. | |
Author | Kay, Alan | |
Access date | 2017-05-11T13:17:40Z | |
Available date | 2017-05-11T13:17:40Z | |
Document date | 2012 | |
Citation | MARTEL, Nora; et al. Probable Corticosteroid-Induced Reactivation of Latent Hepatitis B Virus Infection in an HIV-Positive Patient Involving Immune Escape. The Journal of Infectious Diseases, v.205, p.1757–61, 2012. | pt_BR |
ISSN | 0022-1899 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18814 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Vírus da Hepatite B | pt_BR |
Subject in Portuguese | HIV | pt_BR |
Subject in Portuguese | Pacientes | pt_BR |
Subject in Portuguese | Corticosteróide | pt_BR |
Title | Probable corticosteroid-induced reactivation of latent hepatitis B virus infection in an HIV-positive patient involving immune escape | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/infdis/jis268 | |
Abstract | We describe a patient infected with human immunodeficiency virus who possessed a serological profile suggesting a previous cleared acute hepatitis B virus (HBV) infection, including high levels of antibodies against HBV surface antigen (anti-HBs). Following the administration of inhaled glucocorticosteroids combined with protease inhibitor-based antiretroviral treatment, the patient developed an unexpected severe acute hepatitis despite persistence of anti-HBs. A genotype A2 strain emerged with 2 major mutations in the S gene, sK122R and sD144E. Molecular and biological analyses strongly suggested reactivation of a latent HBV infection. The importance and the molecular basis of these 2 epitopes in immune-escape mechanisms and host-virus interactions are discussed. | pt_BR |
Affilliation | Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France / Hôpital de la Croix-Rousse. Infectious Diseases Unit. Lyon, France. | pt_BR |
Affilliation | Hôpital de la Croix-Rousse. Virology Laboratory. Lyon, France. | pt_BR |
Affilliation | Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France / Hôpital de la Croix-Rousse. Hepato-Gastroenterology Unit. Lyon, France. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France. | pt_BR |
Subject | Hepatitis B Virus Infection | pt_BR |
Subject | HIV-Positive Patient | pt_BR |
Subject | Corticosteroid | pt_BR |
e-ISSN | 1537-6613 | |
Embargo date | 2030-01-01 | |