Author | Pérez, Ana R. | |
Author | Morrot, Alexandre | |
Author | Berbert, Luiz R. | |
Author | Terra-Granado, Eugenia | |
Author | Savino, Wilson | |
Access date | 2017-04-20T16:28:44Z | |
Available date | 2017-04-20T16:28:44Z | |
Document date | 2012 | |
Citation | PÈREZ, Ana R. et al. Extrathymic CD4+CD8+ lymphocytes in Chagas disease: possible relationship with an immunoendocrine imbalance. Ann. N.Y. Acad. Sci., v.1262, p.27–36, 2012. | pt_BR |
ISSN | 0077-8923 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18599 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Doença de Chagas | pt_BR |
Subject in Portuguese | infecção por Trypanosoma cruzi | pt_BR |
Subject in Portuguese | idrocortisona | pt_BR |
Subject in Portuguese | Desidroepiandrosterona | pt_BR |
Subject in Portuguese | Timo | pt_BR |
Subject in Portuguese | Relação CD4-CD8 | pt_BR |
Title | Extrathymic CD4+CD8+ lymphocytes in Chagas disease: possible relationship with an immunoendocrine imbalance | pt_BR |
Type | Article | |
DOI | 10.1111/j.1749-6632.2012.06627.x | |
Abstract | Double-positive (DP) CD4(+) CD8(+) T cells normally represent a thymic subpopulation that is developed in the thymus as a precursor of CD4(+) or CD8(+) single-positive T cells. Recent evidence has shown that DP cells with an activated phenotype can be tracked in secondary lymph organs. The detection of an activated DP population in the periphery, a population that expresses T cell receptors unselected during thymic negative selection in murine models of Trypanosoma cruzi infection and in humans with Chagas disease, raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and its possible link with immunoendocrine alterations. | pt_BR |
Affilliation | National University of Rosario. Faculty of Medical Sciences. Institute of Immunology. Rosario, Argentina. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.l | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Centro de Pesquisa. Programa de Hematologia e Oncologia.Pediátrica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | CD4+CD8+ double-positive CD4+CD8+ T cell | pt_BR |
Subject | thymus | pt_BR |
Subject | Chagas Disease | pt_BR |
Subject | Trypanosoma cruzi infection | pt_BR |
Subject | cortisol | pt_BR |
Subject | dehydroepiandrosterone | pt_BR |
e-ISSN | 1749-6632 | |
Embargo date | 2030-01-01 | |