Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18599
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dc.contributor.authorPérez, Ana R.-
dc.contributor.authorMorrot, Alexandre-
dc.contributor.authorBerbert, Luiz R.-
dc.contributor.authorTerra-Granado, Eugenia-
dc.contributor.authorSavino, Wilson-
dc.date.accessioned2017-04-20T16:28:44Z-
dc.date.available2017-04-20T16:28:44Z-
dc.date.issued2012-
dc.identifier.citationPÈREZ, Ana R. et al. Extrathymic CD4+CD8+ lymphocytes in Chagas disease: possible relationship with an immunoendocrine imbalance. Ann. N.Y. Acad. Sci., v.1262, p.27–36, 2012.pt_BR
dc.identifier.issn0077-8923pt_BR
dc.identifier.urihttp://www.arca.fiocruz.br/handle/icict/18599-
dc.language.isoengpt_BR
dc.publisherWileypt_BR
dc.rightsrestricted accesspt_BR
dc.subject.otherDoença de Chagaspt_BR
dc.subject.otherinfecção por Trypanosoma cruzipt_BR
dc.subject.otheridrocortisonapt_BR
dc.subject.otherDesidroepiandrosteronapt_BR
dc.subject.otherTimopt_BR
dc.subject.otherRelação CD4-CD8pt_BR
dc.titleExtrathymic CD4+CD8+ lymphocytes in Chagas disease: possible relationship with an immunoendocrine imbalancept_BR
dc.typeArticlept_BR
dc.identifier.doi10.1111/j.1749-6632.2012.06627.x-
dc.description.abstractenDouble-positive (DP) CD4(+) CD8(+) T cells normally represent a thymic subpopulation that is developed in the thymus as a precursor of CD4(+) or CD8(+) single-positive T cells. Recent evidence has shown that DP cells with an activated phenotype can be tracked in secondary lymph organs. The detection of an activated DP population in the periphery, a population that expresses T cell receptors unselected during thymic negative selection in murine models of Trypanosoma cruzi infection and in humans with Chagas disease, raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and its possible link with immunoendocrine alterations.pt_BR
dc.creator.affilliationNational University of Rosario. Faculty of Medical Sciences. Institute of Immunology. Rosario, Argentina.pt_BR
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.lpt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Centro de Pesquisa. Programa de Hematologia e Oncologia.Pediátrica. Rio de Janeiro, RJ, Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.pt_BR
dc.subject.enCD4+CD8+ double-positive CD4+CD8+ T cellpt_BR
dc.subject.enthymuspt_BR
dc.subject.enChagas Diseasept_BR
dc.subject.enTrypanosoma cruzi infectionpt_BR
dc.subject.encortisolpt_BR
dc.subject.endehydroepiandrosteronept_BR
dc.identifier.eissn1749-6632-
Appears in Collections:IOC - Artigos de Periódicos

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