Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18598
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBencze, Maximilien-
dc.contributor.authorNegroni, Elisa-
dc.contributor.authorVallese, Denis-
dc.contributor.authorYacoub-Youssef, Houda-
dc.contributor.authorChaouch, Soraya-
dc.contributor.authorWolff, Annie-
dc.contributor.authorAamiri, Ahmed-
dc.contributor.authorDi Santo, James P.-
dc.contributor.authorChazaud, Bénédicte-
dc.contributor.authorButler-Browne, Gillian-
dc.contributor.authorSavino, Wilson-
dc.contributor.authorMouly, Vincent-
dc.contributor.authorRiederer, Ingo-
dc.date.accessioned2017-04-20T16:04:56Z-
dc.date.available2017-04-20T16:04:56Z-
dc.date.issued2012-
dc.identifier.citationBENCZE, Maximilien; et al. Proinflammatory Macrophages Enhance the Regenerative Capacity of Human Myoblasts by Modifying Their Kinetics of Proliferation and Differentiation. Molecular Therapy, v.20, n.11, p.2168-2179, Nov. 2012.pt_BR
dc.identifier.issn1525-0016pt_BR
dc.identifier.urihttp://www.arca.fiocruz.br/handle/icict/18598-
dc.language.isoengpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestricted accesspt_BR
dc.subject.otherMioblastos Humanospt_BR
dc.subject.otherCapacidade Regenerativapt_BR
dc.subject.otherMacrófagos proinflamatóriospt_BR
dc.subject.otherCinéticapt_BR
dc.titleProinflammatory macrophages enhance the regenerative capacity of human myoblasts by modifying their kinetics of proliferation and differentiationpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1038/mt.2012.189-
dc.description.abstractenMacrophages have been shown to be essential for muscle repair by delivering trophic cues to growing skeletal muscle precursors and young fibers. Here, we investigated whether human macrophages, either proinflammatory or anti-inflammatory, coinjected with human myoblasts into regenerating muscle of Rag2(-/-) γC(-/-) immunodeficient mice, could modify in vivo the kinetics of proliferation and differentiation of the transplanted human myogenic precursors. Our results clearly show that proinflammatory macrophages improve in vivo the participation of injected myoblasts to host muscle regeneration, extending the window of proliferation, increasing migration, and delaying differentiation. Interestingly, immunostaining of transplanted proinflammatory macrophages at different time points strongly suggests that these cells are able to switch to an anti-inflammatory phenotype in vivo, which then may stimulate differentiation during muscle regeneration. Conceptually, our data provide for the first time in vivo evidence strongly suggesting that proinflammatory macrophages play a supportive role in the regulation of myoblast behavior after transplantation into preinjured muscle, and could thus potentially optimize transplantation of myogenic progenitors in the context of cell therapy.pt_BR
dc.creator.affilliationCNRS, UMR7215., Institut de Myologie. Paris, France / Université Pierre et Marie Curie. UM76. Paris, France.pt_BR
dc.creator.affilliationCNRS, UMR7215., Institut de Myologie. Paris, France / Université Pierre et Marie Curie. UM76. Paris, France.pt_BR
dc.creator.affilliationCNRS, UMR7215., Institut de Myologie. Paris, France / Université Pierre et Marie Curie. UM76. Paris, France.pt_BR
dc.creator.affilliationINSERM, U1016. Institut Cochin. Paris, France / Université Paris Descartes. Paris, France.pt_BR
dc.creator.affilliationCNRS, UMR7215., Institut de Myologie. Paris, France / Université Pierre et Marie Curie. UM76. Paris, France.pt_BR
dc.creator.affilliationCNRS, UMR7215., Institut de Myologie. Paris, France / Université Pierre et Marie Curie. UM76. Paris, France.pt_BR
dc.creator.affilliationUniversité d’Agadir. Faculté des Sciences. Départment de Biologie. Agadir, Marocco.pt_BR
dc.creator.affilliationInnate Immunity Unit. Inserm U668. Institut Pasteur. Paris, France.pt_BR
dc.creator.affilliationINSERM. U1016. Institut Cochin, Paris, France / Université Paris Descartes. Paris, France.pt_BR
dc.creator.affilliationCNRS, UMR7215., Institut de Myologie. Paris, France / Université Pierre et Marie Curie. UM76. Paris, France.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.pt_BR
dc.creator.affilliationCNRS, UMR7215., Institut de Myologie. Paris, France / Université Pierre et Marie Curie. UM76. Paris, France.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.pt_BR
dc.subject.enproinflammatory macrophagespt_BR
dc.subject.enHuman Myoblastspt_BR
dc.subject.enRegenerative Capacitypt_BR
dc.subject.enkineticspt_BR
dc.identifier.eissn1525-0024-
Appears in Collections:IOC - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
wilson5_savino_etal_IOC_2012.pdf5.91 MBAdobe PDF    Request a copy


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.